Extracellular vesicles and the “six Rs” in radiotherapy

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-07-04 DOI:10.1016/j.ctrv.2024.102799

Isabel Ripoll-Viladomiu , Adriele Prina-Mello , Dania Movia , Laure Marignol

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Abstract

Over half of patients with cancer receive radiation therapy during the course of their disease. Decades of radiobiological research have identified 6 parameters affecting the biological response to radiation referred to as the 6 “Rs”: Repair, Radiosensitivity, Repopulation, Redistribution, Reoxygenation, and Reactivation of the anti-tumour immune response. Extracellular Vesicles (EVs) are small membrane-bound particles whose multiple biological functions are increasingly documented. Here we discuss the evidence for a role of EVs in the orchestration of the response of cancer cells to radiotherapy. We highlight that EVs are involved in DNA repair mechanisms, modulation of cellular sensitivity to radiation, and facilitation of tumour repopulation. Moreover, EVs influence tumour reoxygenation dynamics, and play a pivotal role in fostering radioresistance. Last, we examine how EV-related strategies could be translated into novel strategies aimed at enhancing the efficacy of radiation therapy against cancer.

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细胞外囊泡和放射治疗中的 "六R

一半以上的癌症患者在患病期间会接受放射治疗。数十年的放射生物学研究已经确定了影响生物对辐射反应的 6 个参数，称为 6 "R"：6R "是指：修复、放射敏感性、重新增殖、重新分布、重新氧合和重新激活抗肿瘤免疫反应。细胞外小泡（EVs）是一种膜结合的小颗粒，其多种生物功能已被越来越多地记录在案。在这里，我们讨论了 EVs 在协调癌细胞对放疗的反应中发挥作用的证据。我们强调，EVs 参与了 DNA 修复机制、细胞对辐射敏感性的调节以及促进肿瘤再增殖。此外，EVs 还影响肿瘤复氧动态，并在增强放射抗性方面发挥关键作用。最后，我们将探讨如何将与 EV 相关的策略转化为新型策略，以提高放疗对癌症的疗效。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.