Enzyme-catalyzed hydrolysis of surface polycaprolactone for enhanced cell adhesion on polycaprolactone-based composite scaffolds

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2024-06-24 DOI:10.1016/j.matlet.2024.136908

Zhenhui Liao, Lu Liang, Liya Ma, Limeiting Wang, Zijun Song, Jinhui Huang, Hefeng Yang

引用次数: 0

Abstract

In this study, a porous polycaprolactone (PCL) −based scaffold was treated with lipase to create a hierarchical pore structure. The lipase treatment increased the surface roughness and hydrophilicity, leading to enhanced cell adhesion compared to the untreated scaffold. The hierarchical pore structure of the lipase-treated scaffold shows promise for bone regeneration. This lipase treatment approach offers a new method for designing tissue engineering scaffolds.

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酶催化水解表面聚己内酯，增强聚己内酯基复合支架上的细胞粘附力

在这项研究中，多孔聚己内酯（PCL）基支架经脂肪酶处理后形成了分层孔隙结构。与未经处理的支架相比，脂肪酶处理增加了表面粗糙度和亲水性，从而增强了细胞粘附性。经脂肪酶处理的支架的分层孔隙结构为骨再生带来了希望。这种脂肪酶处理方法为设计组织工程支架提供了一种新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive

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