HA-modified mesoporous Silica/hydroxyapatite hybrid targeted nanoparticles loaded with cabazitaxel and LY294002 for enhanced treatment of triple-negative breast cancer
IF 2.7 4区 材料科学Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Songlin Liu , Xinzhe Shao , Hui Wang , Xinlei Chu , Wenjia Yang , Qingqiang Yao , Pingping Zhang
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引用次数: 0
Abstract
Hyaluronic acid-modified hydroxyapatite-doped mesoporous silica nanoparticle delivery system (CL@M/H-HA) co-delivering the chemotherapeutic agent cabazitaxel (CTX) and the targeted drug PI3K inhibitor LY294002, was constructed for the combination therapy of triple-negative breast cancer (TNBC). CTX and LY294002 had a synergistic effect on MDA-MB-231 cells and the two drugs could be released proportionally and synchronously from the CL@M/H-HA nanoparticles. The hydroxyapatite doped in CL@M/H-HA enabled the drug-carrying system to have a pH-responsive release property. In vitro cellular uptake experiments demonstrated that hyaluronic acid modified on the surface of nanoparticles favored the high uptake efficiency of nanoparticles by tumor cells MDA-MB-231, and nanoparticles co-loaded with CTX and LY294002 could induce more apoptosis of MDA-MB-231 cells. The fabricated dual-loaded targeted nanoparticles could improve the TNBC therapeutic efficacy, providing a promising combination therapy for TNBC.
期刊介绍:
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive