Probe fusion all-optic OCT-PAM dual-mode imaging system for biomedical imaging

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2024-07-01 DOI:10.1016/j.pacs.2024.100631

Ning Ding , Huiwen Jiang , Ben Xiang , Yao Yu , Cheng Ji , Jian Liu , Yuqian Zhao , Jingmin Luan , Yanqiu Yang , Yi Wang , Zhenhe Ma

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引用次数: 0

Abstract

We proposed a non-contact photoacoustic (PA) detection method using spectral domain optical coherence tomography (SDOCT). Two interference spectrums (A-lines) were acquired before and after the PA excitation with SDOCT. PA signal propagated within the sample causing the vibration. The vibration inner the sample introduced phase change between the acquired two A-lines. Thus, the PA signal can be detected by evaluating the difference in phase between the two A-lines. Based on the method, an OCT-PAM dual-mode imaging system was constructed. In the system, SDOCT served as the detection unit for PAM. Thus, the combination of the two imaging modalities was simplified. Another advantage of the system is that it realizes non-contact all-optic detection, which is attractive for biomedical imaging. Using the system, we imaged phantoms of carbon fibers, asparagus leaves and human hairs. Furthermore, the cortical vasculature of rat was imaged in vivo and the flow status was evaluated quantitatively.

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用于生物医学成像的探针融合全光学 OCT-PAM 双模成像系统

我们提出了一种使用光谱域光学相干断层扫描（SDOCT）的非接触式光声（PA）检测方法。利用 SDOCT 获取 PA 激发前后的两个干涉光谱（A 线）。PA 信号在样品内部传播，引起振动。样品内部的振动在获取的两条 A 线之间产生了相位变化。因此，可以通过评估两条 A 线之间的相位差来检测 PA 信号。基于该方法，我们构建了一个 OCT-PAM 双模成像系统。在该系统中，SDOCT 作为 PAM 的检测单元。因此，简化了两种成像模式的结合。该系统的另一个优点是实现了非接触式全光学检测，这对生物医学成像很有吸引力。利用该系统，我们对碳纤维、芦笋叶和人的毛发等模型进行了成像。此外，我们还对大鼠的皮层血管进行了活体成像，并对血流状态进行了定量评估。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.