Recent progresses and challenges on mesoporous silica nanoparticles for DNA-based biosensors and diagnostics

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2024-07-01 DOI:10.1016/j.trac.2024.117846

Milad Baghal Behyar , Azadeh Nilghaz , Mohammad Hasanzadeh , Nasrin Shadjou

{"title":"Recent progresses and challenges on mesoporous silica nanoparticles for DNA-based biosensors and diagnostics","authors":"Milad Baghal Behyar , Azadeh Nilghaz , Mohammad Hasanzadeh , Nasrin Shadjou","doi":"10.1016/j.trac.2024.117846","DOIUrl":null,"url":null,"abstract":"<div><p>Integration of nanomaterials with biomolecule recognition elements is instrumental in advancing biosensor technology. Among possible combinations, mesoporous silica nanoparticles (MSNPs)-deoxyribonucleic acid (DNA) hybrid has been extensively reported for the detection of a wide range of clinically validated biomarkers in biospecimens due to their unique characteristics of excellent sensitivity and selectivity, biocompatibility, and stability. Nonetheless, the challenges to efficiently integrating these hybrids into conventional sensor technologies persist. In this review, we present state-of-the-art and prospects of MSNP in DNA-based sensors for diagnostic applications. We first examine the importance of utilizing MSNPs and DNAs in biosensors and then discuss their integration strategies to achieve enhanced sensitivity and selectivity in quantifying analytical samples. Finally, we outline future trends and practical considerations to address their limitations in various sensing mechanisms.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993624003297","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Integration of nanomaterials with biomolecule recognition elements is instrumental in advancing biosensor technology. Among possible combinations, mesoporous silica nanoparticles (MSNPs)-deoxyribonucleic acid (DNA) hybrid has been extensively reported for the detection of a wide range of clinically validated biomarkers in biospecimens due to their unique characteristics of excellent sensitivity and selectivity, biocompatibility, and stability. Nonetheless, the challenges to efficiently integrating these hybrids into conventional sensor technologies persist. In this review, we present state-of-the-art and prospects of MSNP in DNA-based sensors for diagnostic applications. We first examine the importance of utilizing MSNPs and DNAs in biosensors and then discuss their integration strategies to achieve enhanced sensitivity and selectivity in quantifying analytical samples. Finally, we outline future trends and practical considerations to address their limitations in various sensing mechanisms.

Abstract Image

查看原文本刊更多论文

用于 DNA 生物传感器和诊断的介孔二氧化硅纳米粒子的最新进展与挑战

纳米材料与生物分子识别元件的结合有助于推动生物传感器技术的发展。在各种可能的组合中，介孔二氧化硅纳米颗粒（MSNPs）-脱氧核糖核酸（DNA）混合物因其独特的灵敏度和选择性、生物相容性和稳定性，已被广泛报道用于检测生物样本中各种临床验证的生物标记物。然而，将这些混合技术有效地集成到传统传感器技术中仍然面临挑战。在本综述中，我们将介绍 MSNP 在基于 DNA 的传感器诊断应用中的最新进展和前景。我们首先探讨了在生物传感器中利用 MSNP 和 DNA 的重要性，然后讨论了它们的集成策略，以提高分析样本定量的灵敏度和选择性。最后，我们概述了解决它们在各种传感机制中的局限性的未来趋势和实际考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.