The hydroxypropyl methylcellulose-sorbitol thin film containing a coconut shell of liquid smoke for treating oral ulcer

Q3 Materials Science
Meircurius Dwi Condro Surboyo , Dieni Mansur , Winni Langgeng Kuntari , Sesaria Junita Mega Rahma Syahnia , Benni Iskandar , Ira Arundina , Ta-Wei Liu , Ching-Kuo Lee , Diah Savitri Ernawati
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Abstract

This study aimed to develop an hydroxypropyl methylcellulose-sorbitol (HPMC-sorbitol) thin film as a targeted drug delivery system for coconut shell liquid smoke (CSLS) to effectively treat oral ulcers. The HPMC-sorbitol thin film containing CSLS was created using solvent-casting methods. The resulting thin film underwent comprehensive analysis for shrinkage rate, weight, thickness, water absorption rate, swelling, dissolution, and disintegration time. The producible HPMC-sorbitol thin film containing CSLS exhibited a thickness of 34.89 ± 0.55 μm and a weight of 307.58 ± 10.76 mg, containing phenol and 13-octadecenoic acids. Notably, its swelling, disintegration, and dissolution times were approximately 5 min faster than the blank film. In vitro testing on BHK21 and 7F2 cells demonstrated the thin film's ability to maintain cell viability. In an in vivo oral ulcer model, the thin film reduced neutrophil recruitment, increased macrophage recruitment, and fostered fibroblast proliferation. The HPMC-sorbitol thin film containing CSLS emerged as an effective and well-tolerated delivery system for oral ulcer treatment. Its controlled release mechanism, precise dosing, and protective covering characteristics contribute to enhanced therapeutic outcomes, positioning it as a promising candidate for further development in oral ulcer treatment to improve human health.

Abstract Image

用于治疗口腔溃疡的含有液态烟雾椰壳的羟丙基甲基纤维素-山梨醇薄膜
本研究旨在开发一种羟丙基甲基纤维素-山梨醇(HPMC-山梨醇)薄膜,作为椰壳烟雾剂(CSLS)的靶向给药系统,以有效治疗口腔溃疡。含有 CSLS 的 HPMC-山梨醇薄膜是采用溶剂浇铸法制成的。对所得薄膜的收缩率、重量、厚度、吸水率、膨胀、溶解度和崩解时间进行了综合分析。含有 CSLS 的 HPMC-山梨醇薄膜厚度为 34.89 ± 0.55 μm,重量为 307.58 ± 10.76 mg,其中含有苯酚和 13-十八烯酸。值得注意的是,其溶胀、崩解和溶出时间比空白薄膜快约 5 分钟。对 BHK21 和 7F2 细胞进行的体外测试表明,薄膜能够保持细胞活力。在体内口腔溃疡模型中,薄膜减少了中性粒细胞的募集,增加了巨噬细胞的募集,并促进了成纤维细胞的增殖。含有 CSLS 的 HPMC 山梨醇薄膜是一种有效且耐受性良好的口腔溃疡治疗给药系统。它的控释机制、精确剂量和保护性覆盖特性有助于提高治疗效果,使其有望在口腔溃疡治疗领域得到进一步开发,从而改善人类健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JCIS open
JCIS open Physical and Theoretical Chemistry, Colloid and Surface Chemistry, Surfaces, Coatings and Films
CiteScore
4.10
自引率
0.00%
发文量
0
审稿时长
36 days
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