Rongchen Xu , Changzhen Xu , Yaqi Wang , Lijun Wang , Hongmei Guo , Hongjie Ma , Xu Shen , Shanshan Liu , Shengda Wu , Bingqi Zhao , Yuxiu Liu , Yong Long , Weiguo Hu , Hongbo Li
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引用次数: 0
Abstract
Exogenous electrical stimulation (ES) can significantly enhance the wound healing acceleration. However, most power-generating devices and materials are limited due to structural complexity, external power dependence, and low bio-safety. Here, we design and synthesize a porous hydrogel with gas-solid contact-separation triboelectricity (GSHL). It exhibits excellent physicochemical properties and bio-safety. Also, its inner pores provide a gas-solid interface, which generates a stable self-powered triboelectric potential difference due to the deformation of the interior pores when pressed by the motion of hosts. This exogenous triboelectric stimulation can enhance the proliferation, migration, and adhesion of keratinocytes. In vivo experiments show that GSHL can generate ES at wound bed in situ through the movements of rats, accelerate re-epithelization, and enhance collagen deposition, thereby enhancing the healing of skin wounds. Compared to traditional methods that depending on an external power source to achieve ES for wound healing, this study introduces a novel triboelectric method that is self-powered solely through the intrinsic movement of the organism without any external electrical input.
外源性电刺激(ES)能显著提高伤口愈合的速度。然而,大多数发电装置和材料由于结构复杂、对外部电源的依赖性以及生物安全性低等原因而受到限制。在这里,我们设计并合成了一种具有气固接触分离三电性的多孔水凝胶(GSHL)。它具有优异的物理化学特性和生物安全性。此外,它的内部孔隙提供了一个气固界面,在宿主运动的挤压下,内部孔隙变形,从而产生稳定的自供电三电势差。这种外源性三电势刺激可促进角质细胞的增殖、迁移和粘附。体内实验表明,GSHL 可通过大鼠的运动在伤口床原位产生 ES,加速重新上皮,促进胶原蛋白沉积,从而促进皮肤伤口的愈合。与依赖外部电源实现伤口愈合 ES 的传统方法相比,本研究介绍了一种新颖的三电方法,该方法完全通过生物体的内在运动自我供电,无需任何外部电力输入。
期刊介绍:
Nano Energy is a multidisciplinary, rapid-publication forum of original peer-reviewed contributions on the science and engineering of nanomaterials and nanodevices used in all forms of energy harvesting, conversion, storage, utilization and policy. Through its mixture of articles, reviews, communications, research news, and information on key developments, Nano Energy provides a comprehensive coverage of this exciting and dynamic field which joins nanoscience and nanotechnology with energy science. The journal is relevant to all those who are interested in nanomaterials solutions to the energy problem.
Nano Energy publishes original experimental and theoretical research on all aspects of energy-related research which utilizes nanomaterials and nanotechnology. Manuscripts of four types are considered: review articles which inform readers of the latest research and advances in energy science; rapid communications which feature exciting research breakthroughs in the field; full-length articles which report comprehensive research developments; and news and opinions which comment on topical issues or express views on the developments in related fields.