Cross-sectional and longitudinal associations between late-life depressive symptoms and cognitive deficits: 20-year follow-up of the Kuakini Honolulu-Asia aging study

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Kalpana J. Kallianpur , Hardeep K. Obhi , Timothy Donlon , Kamal Masaki , Bradley Willcox , Peter Martin
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引用次数: 0

Abstract

Objective

To examine depressed affect, somatic complaints, and positive affect as longitudinal predictors of fluid, crystallized and global cognitive performance in the Kuakini Honolulu-Asia Aging Study (HAAS), a large prospective cohort study of Japanese-American men.

Methods

We assessed 3,088 dementia-free Kuakini-HAAS participants aged 71–93 (77.1 ± 4.2) years at baseline (1991–1993). Depressive symptoms were evaluated by the Center for Epidemiologic Studies Depression (CES-D) Scale. Baseline CES-D depression subscales (depressed and positive affects; somatic complaints) were computed. The Cognitive Abilities Screening Instrument (CASI) measured cognitive performance on a 100-point scale; fluid and crystallized cognitive abilities were derived from CASI factor analysis. Cognition was also evaluated at 4 follow-up examinations over a 20-year period. Multiple regression assessed baseline CES-D subscales as predictors of cognitive change. The baseline covariates analyzed were CASI, age, education, prevalent stroke, APOE ε4 presence, and the longevity-associated FOXO3 genotype.

Results

Cross-sectionally, baseline CES-D subscales were related to cognitive measures; e.g., higher depressed affect was associated with lower crystallized ability (β = −0.058, p ≤ 0.01), and somatic complaints were linked to poorer fluid ability (β = −0.045, p ≤ 0.05) and to worse global cognitive function as measured by total CASI score (β = −0.038, p ≤ 0.05). However, depression subscales did not significantly or consistently predict fluid ability, crystallized ability, or global cognitive performance over time.

Conclusion

Psychological and physical well-being were associated with contemporaneous but not subsequent cognitive functioning. Assessment of depressive symptoms may identify individuals who are likely to benefit from interventions to improve mood and somatic health and thereby maintain or enhance cognition.

晚年抑郁症状与认知缺陷之间的横截面和纵向关联:Kuakini 檀香山-亚洲老龄化研究的 20 年随访。
研究目的在一项针对日裔美国男性的大型前瞻性队列研究--Kuakini檀香山-亚洲老龄化研究(HAAS)中,研究抑郁情绪、躯体抱怨和积极情绪对流体、结晶和整体认知表现的纵向预测作用:我们对 3,088 名无痴呆症的 Kuakinii-HAAS 参与者进行了评估,他们的基线年龄为 71-93 岁(77.1 ± 4.2)(1991-1993 年)。抑郁症状采用流行病学研究中心抑郁(CES-D)量表进行评估。计算了基线 CES-D 抑郁症分量表(抑郁和积极情绪;躯体主诉)。认知能力筛查工具(CASI)按 100 分制测量认知能力;流体和晶体认知能力由 CASI 因子分析得出。在 20 年间的 4 次随访检查中也对认知能力进行了评估。多元回归评估了作为认知变化预测因素的基线 CES-D 分量表。分析的基线协变量包括 CASI、年龄、教育程度、脑卒中发病率、APOE ε4存在情况以及与长寿相关的FOXO3基因型:横断面上,基线 CES-D 分量表与认知测量相关,例如,较高的抑郁情绪与较低的结晶能力相关(β = -0.058,p ≤ 0.01),躯体不适与较差的流体能力相关(β = -0.045,p ≤ 0.05),与 CASI 总分测量的较差的整体认知功能相关(β = -0.038,p ≤ 0.05)。然而,随着时间的推移,抑郁分量表并不能显著或持续地预测流体能力、结晶能力或整体认知表现:结论:心理和生理健康与当时的认知功能有关,但与随后的认知功能无关。对抑郁症状的评估可以确定哪些人有可能从改善情绪和躯体健康的干预措施中获益,从而保持或提高认知能力。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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