Unsaturated fatty acids, omega-3 index and hospitalization in MISC

IF 3
Elisabetta Di Profio , Patrizia Risé , Lara Orlandi , Elena Zoia , Christian Pinna , Angelo Sala , Gianvincenzo Zuccotti , Elvira Verduci
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Abstract

The growing interest in Omega-3 fatty acids as diagnostic markers or new therapeutic approaches also for COVID-19 disease, led us to investigate the presence of potential correlations between Omega-3 fatty acids’ levels in whole blood and days of hospitalization or admission to the paediatric intensive care unit (PICU) in 51 children with MIS-C diagnosis following SARS-CoV-2 infection. A statistically significant negative correlation was observed between days of hospitalization and docosapentaenoic acid (22:5n-3,DPA), docosahexaenoic acid (DHA) and total Omega-3 FA levels. Dividing the study group into quartiles according to Omega-3-Index (O3I), no statistically significant difference was observed with respect to the PICU admission rate. In contrast, the number of days of hospitalization in Q4 (O3I ≥ 2.51 %) was different from the number observed in groups Q1-3 (O3I < 2.51 %), with subjects showing higher O3I needing shorter hospitalizations than the subjects with lower O3I. According to previous study investigating O3I in adults affected by Sars-cov-2 we explored the levels of this nutrients in children with MIS-C. Our exploratory study shows that high DPA, DHA and O3I levels could be effective in reducing the length of hospitalization.

MISC 中的不饱和脂肪酸、ω-3 指数和住院情况。
随着人们对 Omega-3 脂肪酸作为 COVID-19 疾病诊断标志物或新治疗方法的兴趣与日俱增,我们对 51 名感染 SARS-CoV-2 后确诊为 MIS-C 的儿童进行了调查,以了解全血中 Omega-3 脂肪酸水平与住院天数或入住儿科重症监护室 (PICU) 天数之间是否存在潜在的相关性。住院天数与二十二碳五烯酸 (22:5n-3,DPA)、二十二碳六烯酸 (DHA) 和总 Omega-3 脂肪酸水平之间存在统计学意义上的明显负相关。根据奥米加-3指数(O3I)将研究组划分为四分位,在PICU入院率方面未观察到显著的统计学差异。相反,第 4 组(O3I ≥ 2.51 %)的住院天数与第 1-3 组(O3I < 2.51 %)的住院天数不同,O3I 较高的受试者比 O3I 较低的受试者住院时间更短。根据之前对受 Sars-cov-2 影响的成人的 O3I 进行的研究,我们探讨了 MIS-C 患儿的营养素水平。我们的探索性研究表明,高 DPA、DHA 和 O3I 水平可有效缩短住院时间。
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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
发文量
0
审稿时长
64 days
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