Protection of Omicron Sub-Lineage Infection Against Reinfection with Another Omicron Sub-Lineage: Systematic Review, Meta-Analysis, and Meta-Regression - Worldwide, 2022-2023.

IF 4.3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

中国疾病预防控制中心周报 Pub Date : 2024-06-28 DOI:10.46234/ccdcw2024.103

Xu Guo, Zuyao Cheng, Junhong Li, Yudan Song, Hui Zheng, Yamin Wang, Chao Ma, Zijian Feng

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Abstract

What is already known about this topic?: Both the decline in immunity over time and the evolution of the virus play a role in the level of protection offered by a prior infection.

What is added by this report?: Point estimates indicated variations in protection levels based on the initial infecting variant and the reinfecting variant. There was a consistent correlation between real-world protection, antigenic distance, and humoral immunity levels. Specifically, shorter antigenic distances and higher humoral immunity levels corresponded to enhanced real-world protection.

What are the implications for public health practice?: Our findings suggest that virological and immunological studies could help identify and assess the epidemic risk posed by new variants before they become dominant. Prompt incorporation of the latest variants into the antigen components of the coronavirus disease 2019 (COVID-19) vaccines can significantly contribute to effective epidemic prevention and control measures.

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欧米克隆亚系感染对再次感染另一欧米克隆亚系的保护：系统综述、元分析和元回归--2022-2023 年全球。

本报告增加了哪些内容？点估算表明，保护水平因最初感染变体和再次感染变体而异。实际保护水平、抗原距离和体液免疫水平之间存在一致的相关性。具体来说，抗原距离越短、体液免疫水平越高，实际保护就越强：我们的研究结果表明，病毒学和免疫学研究有助于在新变种成为主导变种之前识别和评估其造成的流行风险。及时将最新变异株纳入冠状病毒病2019（COVID-19）疫苗的抗原成分可大大促进有效的流行病预防和控制措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国疾病预防控制中心周报

CiteScore

5.90

自引率

0.00%

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