Adding first-line PD-1 inhibition to anti-VEGF and XELOX in pMMR metastatic colorectal cancer: Steppingstones, stumbling blocks, and next phase.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-09-13 Epub Date: 2024-07-03 DOI:10.1016/j.medj.2024.06.006

Torhild Veen, Kjetil Søreide

引用次数: 0

Abstract

In the randomized, double-blind, multicenter study by Wang et al.,¹ the addition of serplulimab (a PD-1 antibody) to anti-VEGF (HLX04; a bevacizumab biosimilar) together with chemotherapy (XELOX) was deemed to be tolerable and safe and may improve progression-free survival. However, even if adverse events were comparable, oncological endpoints including survival need to be confirmed in the next phase 3 study.

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在抗血管内皮生长因子和 XELOX 治疗 pMMR 转移性结直肠癌的一线治疗中加入 PD-1 抑制剂：垫脚石、绊脚石和下一阶段。

在Wang等人1的随机、双盲、多中心研究中，在抗血管内皮生长因子（HLX04；贝伐珠单抗的生物类似物）和化疗（XELOX）中加入serplulimab（一种PD-1抗体）被认为是可耐受的、安全的，并可改善无进展生存期。不过，即使不良事件具有可比性，包括生存期在内的肿瘤学终点仍需在下一项三期研究中得到确认。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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