Ovarian cancer risk factors in relation to family history.

IF 9.9 1区 医学 Q1 ONCOLOGY
Guoqiao Zheng, Louise Baandrup, Jiangrong Wang, Rasmus Hertzum-Larsen, Charlotte Gerd Hannibal, Mette Tuxen Faber, Karin Sundström, Susanne K Kjær
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引用次数: 0

Abstract

Background: Women with a family history of breast and/or ovarian cancer have an increased ovarian cancer risk. Yet it remains uncertain if common ovarian cancer risk factors-especially those that are modifiable-affect this high-risk population similarly to the general population.

Methods: Using the Danish and Swedish nationwide registers, we established 2 nested case-control study populations in women with a family history of breast and/or ovarian cancer (2138 ovarian cancers, 85 240 controls) and women without (10 730 ovarian cancers, 429 200 controls). The overall and histology-specific associations were assessed with conditional logistic regression. The country-specific estimates were combined based on a fixed-effect assumption.

Results: Multiparity, hysterectomy, tubal ligation, salpingectomy, and oral contraceptive (OC) use were associated with a reduced risk of ovarian cancer in women with and without a family history, while endometriosis and menopausal hormone therapy were associated with increased risk. Multiparity and OC use presented protective effects across all histologic subtypes except mucinous ovarian cancer, which was not associated with OC use. Menopausal hormone treatment increased the risk of serous ovarian cancer but decreased the risk of the mucinous and clear cell cancers. Endometriosis was especially related to an increased risk of endometrioid and clear cell ovarian cancer.

Conclusion: Factors associated with a decreased ovarian cancer risk were similar between women with and without a family history of breast and/or ovarian cancer. Given the higher baseline risk for women with a family history, special attention should be paid to risk factors like endometriosis and nulliparity in this high-risk population.

卵巢癌风险因素与家族史的关系。
背景:有乳腺癌和/或卵巢癌家族史的妇女患卵巢癌的风险会增加。然而,常见的卵巢癌风险因素--尤其是那些可改变的因素--对这一高风险人群的影响是否与普通人群相似,目前仍不确定:方法:我们利用丹麦和瑞典的全国登记册,在有乳腺癌和/或卵巢癌家族史的妇女(2138 例卵巢癌,85240 例对照)和无家族史的妇女(10730 例卵巢癌,429200 例对照)中建立了两个巢式病例对照研究人群。通过条件逻辑回归评估了总体和组织学特异性关联。根据固定效应假设合并了各国的估计值:结果:多产妇、子宫切除术、输卵管结扎术、输卵管切除术和口服避孕药(OC)与有家族史和无家族史妇女卵巢癌风险的降低有关,而子宫内膜异位症和绝经期激素治疗(MHT)与风险的增加有关。多胎性和使用OC对所有组织学亚型都有保护作用,但粘液性卵巢癌与使用OC无关。MHT会增加浆液性卵巢癌的风险,但会降低粘液腺癌和透明细胞癌的风险。子宫内膜异位症尤其与子宫内膜样癌和透明细胞卵巢癌风险增加有关:与卵巢癌风险降低相关的因素在有乳腺癌和/或卵巢癌家族史和无家族史的妇女中相似。鉴于有家族史的妇女的基线风险较高,应特别关注这一高风险人群中的子宫内膜异位症和无排卵等风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.00
自引率
2.90%
发文量
203
审稿时长
4-8 weeks
期刊介绍: The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.
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