Associations between menopausal symptoms and cardiovascular disease in middle-aged Chinese women.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-04 DOI:10.1080/13697137.2024.2368479

Xueyin Wang, Juan Juan, Di Gao, Bo Song, Xiaosong Zhang

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引用次数: 0

Abstract

Objective: This study aimed to examine the association between severity of menopausal symptoms and cardiovascular disease (CVD) risk among middle-aged Chinese women.

Methods: A cross-sectional study recruited 9679 women aged 40-70 years from three socioeconomic regions of China in 2018. Menopausal symptoms were assessed by the modified Kupperman Menopausal Index (KMI). The severity of individual symptoms was classified as none (0 points), mild (1 points) and moderate-to-severe symptoms (2-3 points), and overall menopausal symptoms were classified as none (<15 points), mild (15-24 points) or moderate-to-severe (≥25 points) according to the sum score of the KMI. Logistic regression models were used to examine associations of the severity of menopausal symptoms with CVD risk.

Results: A total of 5.6% of participants reported being diagnosed with CVD. Overall menopausal symptoms were more common in women aged 60-70 years than in women aged 40-59 years. After multiple adjustment, mild (odds ratio [OR] = 2.07, 95% confidence interval [CI]: 1.64-2.61) and moderate-to-severe (OR = 2.64, 95% CI: 1.92-3.63) overall menopausal symptoms were associated with increased risk of CVD compared with no symptoms. Significant positive associations between the severity of individual menopausal symptoms and CVD risk were observed for all 13 items.

Conclusion: The severity of menopausal symptoms was positively associated with CVD risk in middle-aged Chinese women.

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中国中年女性更年期症状与心血管疾病之间的关系。

目的：本研究旨在探讨中国中年女性更年期症状的严重程度与心血管疾病风险之间的关系：本研究旨在探讨中国中年女性更年期症状严重程度与心血管疾病（CVD）风险之间的关系：一项横断面研究于2018年从中国三个社会经济地区招募了9679名40-70岁的女性。更年期症状通过改良的库珀曼更年期指数（KMI）进行评估。单个症状的严重程度分为无（0 分）、轻度（1 分）和中重度症状（2-3 分），总体更年期症状分为无（结果：共有 5.6% 的参与者被诊断患有心血管疾病。与 40-59 岁的女性相比，60-70 岁的女性更容易出现更年期综合症状。经多重调整后，与无症状相比，轻度（比值比 [OR] = 2.07，95% 置信区间 [CI]：1.64-2.61）和中度至重度（比值比 [OR] = 2.64，95% 置信区间 [CI]：1.92-3.63）更年期综合症状与心血管疾病风险增加有关。在所有13个项目中，都观察到个别更年期症状的严重程度与心血管疾病风险之间存在显著的正相关：结论：中国中年女性更年期症状的严重程度与心血管疾病风险呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.