NLRP3 Expression and Its Predictive Role in Heart Failure with Preserved Ejection Fraction among Non-Valvular Atrial Fibrillation Patients.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Pub Date : 2024-07-17 DOI:10.1159/000540204

Shijian Chen, Ziheng Yu, Wen Wen, Jiming Chen, Kongjie Lu

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引用次数: 0

Abstract

Introduction: The aim of this study was to investigate the expression and predictive value of NOD-like receptor thermal protein domain-related protein 3 (NLRP3) in patients with non-valvular atrial fibrillation (NVAF) with heart failure with preserved ejection fraction (HFpEF).

Methods: This was a retrospective analysis of 121 patients diagnosed with NVAF. According to the occurrence of HFpEF, 81 patients were assigned to the NVAF group and 40 patients to the NVAF/HFpEF group. The levels of NLRP3, B natriuretic peptide (BNP), and interleukin-1β (IL-1β) were determined using ELISA. Independent predictors for HFpEF in NVAF were determined using logistic regression. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of each factor.

Results: Expression levels of NLRP3, BNP, and IL-1β in the NVAF/HFpEF group, as well as the H2FPEF score were significantly higher than those in the NVAF group. Pearson analysis showed that NLRP3, BNP, and IL-1β expression levels in NVAF patients and the H2FPEF score was positively correlated (r = 0.409, r = 0.244, r = 0.299, p < 0.001). Multivariate logistic regression analysis showed that the NLRP3, BNP, or H2FPEF score can be used as independent factor for predicting the occurrence of HFpEF in NVAF. ROC curves showed that the areas under the curve of NLRP3, BNP, and H2FPEF scores for predicting the occurrence of HFpEF in NVAF patients were 0.856, 0.831, and 0.811, respectively.

Conclusion: The NLRP3 level is elevated in the peripheral blood of NVAF patients with HFpEF and is positively correlated with the H2FPEF score. NLRP3 may serve as a potential predictor of HFpEF in patients with NVAF.

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NLRP3 表达及其对非瓣膜性心房颤动患者保留射血分数的预测作用。

导言研究NOD样受体热蛋白结构域相关蛋白3（NLRP3）在非瓣膜性心房颤动（NVAF）伴射血分数保留性心力衰竭（HFpEF）患者中的表达和预测价值：方法：对121例确诊为非瓣膜性心房颤动（NVAF）的患者进行回顾性分析。方法：对121例被诊断为NVAF的患者进行回顾性分析，根据HFpEF的发生情况，81例患者被分配到NVAF组，40例患者被分配到NVAF/HFpEF组。采用酶联免疫吸附试验（ELISA）测定了 NLRP3、BNP 和白细胞介素-1β的水平。采用逻辑回归法确定了 NVAF 中 HFpEF 的独立预测因子。采用接收者操作特征曲线（ROC）评估各因素的预测价值：结果：NVAF/HFpEF组中NLRP3、BNP和IL-1β的表达水平以及H2FPEF评分均显著高于NVAF组。Pearson分析显示，NVAF患者的NLRP3、BNP和IL-1β表达水平与H2FPEF评分呈正相关（r=0.409，r=0.244，r=0.299，p <0.001）。多变量逻辑回归分析表明，NLRP3、BNP或H2FPEF评分可作为预测NVAF发生HFpEF的独立因素。ROC曲线显示，NLRP3、BNP和H2FPEF评分预测NVAF患者发生HFpEF的曲线下面积（AUC）分别为0.856、0.831和0.811：结论：NVAF患者外周血中NLRP3水平升高，且与H2FPEF评分呈正相关。NLRP3可作为预测NVAF患者HFpEF的潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology 医学-心血管系统

CiteScore

3.40

自引率

5.30%

发文量

审稿时长

1.5 months

期刊介绍： ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.