Asmaa H. Abbas, Theia’a N. Al-Sabha, Subhi M. J. Al-Mtwaiti
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引用次数: 0
Abstract
A spectrophotometric method has been developed for the determination of certain amine-phenol-containing drugs, namely, adrenaline, phenylephrine hydrochloride, and terbutaline sulfate. The method depends on the formation of new products by the reaction of drugs with the Gibbs reagent (2,6-dichloroquinone-4-chloroamide) in a basic borate buffer medium with a pH value of 11. The products were measured at 475, 652.5, and 547 nm for the aforementioned drugs, respectively. Beer–Lambert law was obeyed in the ranges of 0.3–9.5, 0.5–17, and 0.5–55 µg/mL with average recovery of 101.10, 99.13, and 99.78% and a relative standard deviation of ≤3.31%, respectively. The method was free from excipient interferences and applied successfully for the assay of the studied drugs in their pharmaceutical formulations. The resulting products were found in the ratio of 1 : 1.
期刊介绍：
The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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