{"title":"Application of biomaterials in the treatment of intracerebral hemorrhage","authors":"Wei Wang, Xiaowen Liu, Yupeng Wang, Dongfang Zhou and Lukui Chen","doi":"10.1039/D4BM00630E","DOIUrl":null,"url":null,"abstract":"<p >Although the current surgical hematoma removal treatment saves patients’ lives in critical moments of intracerebral hemorrhage (ICH), the lethality and disability rates of ICH are still very high. Due to the individual differences of patients, postoperative functional improvement is still to be confirmed, and the existing drug treatment has limited benefits for ICH. Recent advances in biomaterials may provide new ideas for the therapy of ICH. This review first briefly describes the pathogenic mechanisms of ICH, including primary and secondary injuries such as inflammation and intracerebral edema, and briefly describes the existing therapeutic approaches and their limitations. Secondly, existing nanomaterials and hydrogels for ICH, including exosomes, liposomes, and polymer nanomaterials, are also described. In addition, the potential challenges and application prospects of these biomaterials for clinical translation in ICH treatment are discussed.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 16","pages":" 4065-4082"},"PeriodicalIF":5.7000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials Science","FirstCategoryId":"5","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/bm/d4bm00630e","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Although the current surgical hematoma removal treatment saves patients’ lives in critical moments of intracerebral hemorrhage (ICH), the lethality and disability rates of ICH are still very high. Due to the individual differences of patients, postoperative functional improvement is still to be confirmed, and the existing drug treatment has limited benefits for ICH. Recent advances in biomaterials may provide new ideas for the therapy of ICH. This review first briefly describes the pathogenic mechanisms of ICH, including primary and secondary injuries such as inflammation and intracerebral edema, and briefly describes the existing therapeutic approaches and their limitations. Secondly, existing nanomaterials and hydrogels for ICH, including exosomes, liposomes, and polymer nanomaterials, are also described. In addition, the potential challenges and application prospects of these biomaterials for clinical translation in ICH treatment are discussed.
脑内出血（ICH）致死率和致残率仍然很高，虽然目前的手术血肿清除治疗在ICH的关键时刻挽救了患者的生命，但由于患者的实际时空、个体差异不同，术后患者的功能改善仍有待证实，现有的药物治疗对ICH的益处有限。生物材料的最新进展可能会为 ICH 的药物治疗提供新的思路。纳米材料能够靶向和协同治疗，从而提高疗效并减轻副作用。本综述首先简要介绍了 ICH 的致病机制，包括原发性和继发性损伤，如炎症和脑内水肿，并简要介绍了现有的治疗方法及其局限性。其次，还介绍了治疗 ICH 的现有纳米材料和水凝胶，包括外泌体、脂质体和聚合物纳米材料。其中一些纳米材料可有效携带药物穿过血脑屏障（BBB），通过负载药物或其他分子的纳米递送策略发挥治疗效果。此外，还讨论了这些递送平台在临床转化方面的潜在挑战和应用前景。
期刊介绍：
Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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