Centrifugally spun hydroxyapatite/carbon composite nanofiber scaffolds for bone tissue engineering

IF 3.1 Q2 MATERIALS SCIENCE, COMPOSITES
Yasin Akgul, Elena Stojanovska, Mehmet Durmus Calisir, Yusuf Polat and Ali Kilic
{"title":"Centrifugally spun hydroxyapatite/carbon composite nanofiber scaffolds for bone tissue engineering","authors":"Yasin Akgul, Elena Stojanovska, Mehmet Durmus Calisir, Yusuf Polat and Ali Kilic","doi":"10.1088/2631-6331/ad5b49","DOIUrl":null,"url":null,"abstract":"In recent years, advancements in tissue engineering have demonstrated the potential to expedite bone matrix formation, leading to shorter recovery times and decreased clinical challenges compared to conventional methods. Therefore, this study aims to develop composite carbon nanofibers (CNFs) integrated with nano-hydroxyapatite (nHA) particles as scaffolds for bone tissue engineering applications. A key strategy in achieving this objective involves harnessing nanofibrous structures, which offer a high surface area, coupled with nHA particles expected to accelerate bone regeneration and enhance biological activity. To realize this, polyacrylonitrile (PAN)/nHA nanofibers were fabricated using the centrifugal spinning (C-Spin) technique and subsequently carbonized to yield CNF/nHA composite structures. Scanning Electron Microscopy (SEM) confirmed C-Spin as a suitable method for PAN and CNF nanofiber production, with nHA particles uniformly dispersed throughout the nanofibrous structure. Carbonization resulted in reduced fiber diameter due to thermal decomposition and shrinkage of PAN molecules during the process. Furthermore, the incorporation of nHA particles into PAN lowered the stabilization temperature (by 5 °C–20 °C). Tensile tests revealed that PAN samples experienced an approximately 80% increase in ultimate tensile strength and a 187% increase in modulus with a 5 wt.% nHA loading. However, following carbonization, CNF samples exhibited a 50% decrease in strength compared to PAN samples. Additionally, the addition of nHA into CNF improved the graphitic structure. The incorporation of nHA particles into the spinning solution represents a viable strategy for enhancing CNF bioactivity.","PeriodicalId":12652,"journal":{"name":"Functional Composites and Structures","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Functional Composites and Structures","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/2631-6331/ad5b49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0

Abstract

In recent years, advancements in tissue engineering have demonstrated the potential to expedite bone matrix formation, leading to shorter recovery times and decreased clinical challenges compared to conventional methods. Therefore, this study aims to develop composite carbon nanofibers (CNFs) integrated with nano-hydroxyapatite (nHA) particles as scaffolds for bone tissue engineering applications. A key strategy in achieving this objective involves harnessing nanofibrous structures, which offer a high surface area, coupled with nHA particles expected to accelerate bone regeneration and enhance biological activity. To realize this, polyacrylonitrile (PAN)/nHA nanofibers were fabricated using the centrifugal spinning (C-Spin) technique and subsequently carbonized to yield CNF/nHA composite structures. Scanning Electron Microscopy (SEM) confirmed C-Spin as a suitable method for PAN and CNF nanofiber production, with nHA particles uniformly dispersed throughout the nanofibrous structure. Carbonization resulted in reduced fiber diameter due to thermal decomposition and shrinkage of PAN molecules during the process. Furthermore, the incorporation of nHA particles into PAN lowered the stabilization temperature (by 5 °C–20 °C). Tensile tests revealed that PAN samples experienced an approximately 80% increase in ultimate tensile strength and a 187% increase in modulus with a 5 wt.% nHA loading. However, following carbonization, CNF samples exhibited a 50% decrease in strength compared to PAN samples. Additionally, the addition of nHA into CNF improved the graphitic structure. The incorporation of nHA particles into the spinning solution represents a viable strategy for enhancing CNF bioactivity.
用于骨组织工程的离心纺丝羟基磷灰石/碳复合纳米纤维支架
近年来,组织工程学的进步证明了加快骨基质形成的潜力,与传统方法相比,可缩短恢复时间,减少临床挑战。因此,本研究旨在开发集成了纳米羟基磷灰石(nHA)颗粒的复合碳纳米纤维(CNFs),作为骨组织工程应用的支架。实现这一目标的关键策略是利用具有高表面积的纳米纤维结构与 nHA 颗粒相结合,从而加速骨再生并提高生物活性。为了实现这一目标,我们采用离心纺丝(C-Spin)技术制造了聚丙烯腈(PAN)/nHA 纳米纤维,随后对其进行碳化处理,得到了 CNF/nHA 复合结构。扫描电子显微镜(SEM)证实 C-Spin 是生产 PAN 和 CNF 纳米纤维的合适方法,nHA 颗粒均匀地分散在整个纳米纤维结构中。碳化过程中 PAN 分子的热分解和收缩导致纤维直径减小。此外,在 PAN 中加入 nHA 颗粒降低了稳定温度(5 ℃-20 ℃)。拉伸试验显示,PAN 样品在添加 5 wt.% 的 nHA 后,极限拉伸强度提高了约 80%,模量提高了 187%。然而,在碳化之后,CNF 样品的强度比 PAN 样品降低了 50%。此外,在 CNF 中添加 nHA 还能改善石墨结构。在纺丝溶液中加入 nHA 颗粒是提高 CNF 生物活性的可行策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Functional Composites and Structures
Functional Composites and Structures Materials Science-Materials Science (miscellaneous)
CiteScore
4.80
自引率
10.70%
发文量
33
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信