Recent advancements in flavonoid production through engineering microbial systems

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Yunhee Hwang, Myung Hyun Noh, Gyoo Yeol Jung
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Abstract

Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic, and food industries. Currently, flavonoid production largely depends on plant extraction methods, which face limitations owing to low yields and seasonal and environmental impacts. To address these issues, the potential of microbial fermentation, which leverages advances in metabolic engineering and genetic tools, has been discussed as an innovative alternative to overcome these challenges, thus offering an environmentally friendly and sustainable approach to flavonoid production. However, the integration of complex biosynthesis pathways into microbial systems presents challenges such as the inefficient expression of plant-derived genes, metabolic conflicts, and toxicity or feedback inhibition by accumulated flavonoids within the microbial cells. This comprehensive review highlights recent advancements in engineering strategies to address these challenges, focusing on biotransformation, single-strain fermentation, and co-culture systems, each with its own unique characteristics and potential for optimizing flavonoid production in a cost-effective and scalable manner.

Abstract Image

通过工程微生物系统生产黄酮类化合物的最新进展
类黄酮是一类存在于植物中的多酚化合物,具有广泛的保健功效,可应用于制药、化妆品和食品行业。目前,黄酮类化合物的生产主要依赖于植物提取方法,这种方法由于产量低、受季节和环境影响而受到限制。为了解决这些问题,人们讨论了微生物发酵的潜力,认为微生物发酵利用了代谢工程和遗传工具的进步,是克服这些挑战的创新替代方法,从而为黄酮类化合物的生产提供了一种环境友好型和可持续发展的方法。然而,将复杂的生物合成途径整合到微生物系统中会带来一些挑战,如植物源基因的低效表达、代谢冲突以及微生物细胞内积累的类黄酮的毒性或反馈抑制作用。本综述重点介绍了应对这些挑战的工程策略的最新进展,重点关注生物转化、单菌种发酵和共培养系统,每种系统都有其独特的特点和潜力,可以以具有成本效益和可扩展的方式优化类黄酮的生产。
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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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