Cerebrospinal Fluid Nitric Oxide Synthase is a Potential Mediator Between Cigarette Smoke Exposure and Sleep Disorders

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-07-01 DOI:10.2147/nss.s458294

Jiaying Lao, Hang Tan, Yuyu Wu, Ting Ding, Xinqian Liu, Lanrong Sun, Xiyi Chen, Chongrong Zhu, Yiming Kang, Yu-Hsin Chen, Chonghui Tang, Fan Wang, Yanlong Liu

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引用次数: 0

Abstract

Objective: Cigarette smoking and low peripheral nitric oxide synthase (NOS) levels are strongly associated with sleep disorders. However, whether cerebrospinal fluid (CSF) NOS relates to sleep disorders and whether CSF NOS mediates the relationship between cigarette smoking and sleep disorders is unclear.
Methods: We measured CSF levels of total NOS (tNOS) and its isoforms (inducible NOS [iNOS] and constitutive NOS [cNOS]) in 191 Chinese male subjects. We applied the Pittsburgh Sleep Quality Index (PSQI).
Results: The PSQI scores of active smokers were significantly higher than those of non-smokers, while CSF tNOS, iNOS, and cNOS were significantly lower (all p < 0.001). CSF tNOS, iNOS, and cNOS were negatively associated with PSQI scores in the general population (all p < 0.001). Mediation analysis suggested that CSF tNOS, iNOS, and cNOS mediate the relationship between smoking and PSQI scores, and the indirect effect accounted for 78.93%, 66.29%, and 81.65% of the total effect, respectively.
Conclusion: Cigarette smoking is associated with sleep disorders. Active smokers had significantly lower CSF levels of tNOS, iNOS, and cNOS. Furthermore, tNOS, iNOS, and cNOS mediate the relationship between cigarette smoking and sleep quality. This study provides insights into how cigarette smoke affects sleep disorders.

Keywords: cerebrospinal fluid nitric oxide synthase, cigarette smoking, Pittsburgh Sleep Quality Index, sleep disorders, mediation

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脑脊液一氧化氮合成酶是香烟烟雾暴露与睡眠障碍之间的潜在媒介

目的：吸烟和外周一氧化氮合酶（NOS）水平低与睡眠障碍密切相关。然而，脑脊液（CSF）中的一氧化氮是否与睡眠障碍有关，以及脑脊液中的一氧化氮是否介导吸烟与睡眠障碍之间的关系，目前尚不清楚：我们测量了 191 名中国男性受试者脑脊液中总 NOS（tNOS）及其同工酶（诱导型 NOS [iNOS] 和组成型 NOS [cNOS]）的水平。我们采用了匹兹堡睡眠质量指数（PSQI）：结果：主动吸烟者的 PSQI 分数明显高于非吸烟者，而 CSF tNOS、iNOS 和 cNOS 则明显低于主动吸烟者（所有 p 均为 0.001）。CSF tNOS、iNOS 和 cNOS 与普通人群的 PSQI 分数呈负相关（所有 p 均为 0.001）。中介分析表明，CSF tNOS、iNOS 和 cNOS 在吸烟与 PSQI 分数之间起中介作用，间接效应分别占总效应的 78.93%、66.29% 和 81.65%：结论：吸烟与睡眠障碍有关。积极吸烟者的脑脊液中 tNOS、iNOS 和 cNOS 水平明显较低。此外，tNOS、iNOS 和 cNOS 对吸烟与睡眠质量之间的关系起着中介作用。这项研究为了解吸烟如何影响睡眠障碍提供了见解。关键词：脑脊液一氧化氮合酶；吸烟；匹兹堡睡眠质量指数；睡眠障碍；中介作用

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.