Effects of Ovarian Gonadotropin Stimulation under Conditions of Chronic Psychosocial Stress on the Quality of Murine Oocytes

IF 0.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Evolutionary Biochemistry and Physiology Pub Date : 2024-06-26 DOI:10.1134/s0022093024030244

D. A. Lebedeva, T. N. Igonina, E. Yu. Brusentsev, N. A. Shavshaeva, S. Ya. Amstislavsky

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Abstract

Chronic psychosocial stress can negatively affect the female reproductive system. Meanwhile, the effect of ovarian stimulation with gonadotropins during stress on the quality of oocytes remains poorly studied. This work was aimed to investigate the effects of chronic psychosocial stress on the quality of murine cumulus-oocyte complexes under the natural estrus cycle, as well as during the ovarian stimulation with exogenous gonadotropins, which is an important part of modern assisted reproductive technologies. Here we demonstrate that psychosocial stress does not affect the number of ovulating oocytes but deteriorates their quality, i.e. reduces the percentage of mature oocytes. In addition, stressed mice exhibited an enhanced accumulation of reactive oxygen species (ROS) in oocytes, accompanied by an increased apoptosis level in cumulus cells. Hormonal stimulation of the ovaries with gonadotropins alleviates the negative changes associated with psychosocial stress, normalizing ROS overproduction in oocytes and reducing apoptosis levels in cumulus cells.

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慢性社会心理压力条件下的促性腺激素刺激对小鼠卵母细胞质量的影响

摘要长期的社会心理压力会对女性生殖系统产生负面影响。同时，关于应激时促性腺激素刺激卵巢对卵母细胞质量的影响的研究仍然较少。本研究旨在探讨在自然发情周期下，以及作为现代辅助生殖技术重要组成部分的外源性促性腺激素卵巢刺激过程中，慢性社会心理应激对小鼠卵母细胞质量的影响。在这里，我们证明了社会心理应激不会影响排卵卵母细胞的数量，但会降低其质量，即减少成熟卵母细胞的比例。此外，应激小鼠卵母细胞中活性氧（ROS）的积累增加，同时积层细胞的凋亡水平也增加。用促性腺激素对卵巢进行荷尔蒙刺激可缓解与心理社会压力相关的负面变化，使卵母细胞中过量产生的 ROS 恢复正常，并降低积层细胞的凋亡水平。

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来源期刊

Journal of Evolutionary Biochemistry and Physiology 生物-进化生物学

自引率

33.30%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.