K. V. Apukhtin, A. D. Shevlyakov, M. M. Kotova, S. V. Amikishiev, V. D. Riga, A. D. Volgin, A. V. Kalueff
{"title":"Analysis of Rodent Grooming and Its Microstructure in Modern Neurobiological Studies","authors":"K. V. Apukhtin, A. D. Shevlyakov, M. M. Kotova, S. V. Amikishiev, V. D. Riga, A. D. Volgin, A. V. Kalueff","doi":"10.1134/s0022093024030219","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Grooming is a complex innate animal behavior that can serve\nas a marker of physiological state of rodents under stress. Here,\nwe analyze the impact of various experimental factors, including\ngenetic, pharmacological and physiological, on self-grooming behavior\nof laboratory mice and rats. Analyses of grooming behavior assess\nnot only the number and duration of its bouts but also its microstructure,\ni.e. frequency, sequence, localization, and consistency. Rodent\ngrooming and its microstructure can serve as a sensitive marker\nfor changes in the brain, its response to stress, and predisposition\nto pathological conditions simulating such human mental disorders\nas obsessive-compulsive disorder, autism and depression. Studying\nrodent self-grooming microstructure can provide valuable information\nabout the mechanisms of brain pathogenesis, having multiple translational\nimplications for neuroscience research.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"31 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evolutionary Biochemistry and Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0022093024030219","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Grooming is a complex innate animal behavior that can serve
as a marker of physiological state of rodents under stress. Here,
we analyze the impact of various experimental factors, including
genetic, pharmacological and physiological, on self-grooming behavior
of laboratory mice and rats. Analyses of grooming behavior assess
not only the number and duration of its bouts but also its microstructure,
i.e. frequency, sequence, localization, and consistency. Rodent
grooming and its microstructure can serve as a sensitive marker
for changes in the brain, its response to stress, and predisposition
to pathological conditions simulating such human mental disorders
as obsessive-compulsive disorder, autism and depression. Studying
rodent self-grooming microstructure can provide valuable information
about the mechanisms of brain pathogenesis, having multiple translational
implications for neuroscience research.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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