{"title":"Role of NLRP3 Inflammasome in Pathogenesis of Ischemic Stroke","authors":"S. D. Kazakov, E. M. Kamenskih, E. V. Udut","doi":"10.1134/s0022093024030098","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Ischemic stroke (IS) is a prevalent condition worldwide with\nhigh mortality and disability risks. The issue of its pathogenetic\ntherapy remains unresolved by now due to the limited effectiveness\nand safety of reperfusion measures. Recent research has elucidated\nthat neuroinflammation plays a pivotal role in IS development and\nmay serve as a therapeutic target. The NLRP3 inflammasome emerges\nas a key mediator orchestrating post-ischemic inflammatory reactions\nthrough activation of caspase-1, which cleaves pro-IL-1β and pro-IL-18\ninto active pro-inflammatory cytokines released into the extracellular milieu.\nThis review presents insights into the structure and activation\nprocess of the NLRP3 inflammasome in IS. The factors and mechanisms\ncontributing to both its activation and inhibition are outlined.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"43 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evolutionary Biochemistry and Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0022093024030098","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ischemic stroke (IS) is a prevalent condition worldwide with
high mortality and disability risks. The issue of its pathogenetic
therapy remains unresolved by now due to the limited effectiveness
and safety of reperfusion measures. Recent research has elucidated
that neuroinflammation plays a pivotal role in IS development and
may serve as a therapeutic target. The NLRP3 inflammasome emerges
as a key mediator orchestrating post-ischemic inflammatory reactions
through activation of caspase-1, which cleaves pro-IL-1β and pro-IL-18
into active pro-inflammatory cytokines released into the extracellular milieu.
This review presents insights into the structure and activation
process of the NLRP3 inflammasome in IS. The factors and mechanisms
contributing to both its activation and inhibition are outlined.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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