{"title":"Maternal Methyl-Enriched Diet Improves Episodic Memory but Does Not Affect Conditioned Fear Memory in Offspring of WAG/Rij Rats","authors":"E. A. Fedosova, A. B. Shatskova, K. Yu. Sarkisova","doi":"10.1134/s0022093024030311","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This study was aimed to find out what effect the maternal\nmethyl-enriched diet (MED) in the perinatal period exerts on cognitive\nfunctions in adult offspring of WAG/Rij rats, a genetic model of\nabsence epilepsy with comorbid depression. The cognitive functions\n(learning and memory) were evaluated in the novel object recognition\n(NOR) and fear conditioning (for fear memory) tests. The experiments\nwere carried out on 6-month-old male WAG/Rij rats. The mothers of\nthe experimental group fed a MED, while the mothers of the control\ngroup fed a control diet. The NOR test was used to assess episodic memory.\nThis test is based on innate exploratory (novelty preference) motivation,\nwhich is usually reduced in depression. The conditioning of fear\nmemory is the classical Pavlovian defensive conditioned reflex,\nmanifested as freezing in response to negative reinforcement (electric\nfootshock). In the NOR test, in rats of the experimental group,\nthe novel object recognition index (a measure of episodic memory)\nand the number of entries to the center of the arena (a measure\nof exploratory motivation) were significantly higher compared to\nthe corresponding measures in the control group. However, no intergroup\ndifferences were revealed in the manifestation of conditioned fear\nmemory (% of freezing responses) to a context and a sound cue. The\nresults indicate that the maternal MED improves episodic memory\nin the NOR test but does not affect the conditioned fear memory\nassociated with a context and sound cue in the adult offspring of\nWAG/Rij rats.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"10871 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evolutionary Biochemistry and Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0022093024030311","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study was aimed to find out what effect the maternal
methyl-enriched diet (MED) in the perinatal period exerts on cognitive
functions in adult offspring of WAG/Rij rats, a genetic model of
absence epilepsy with comorbid depression. The cognitive functions
(learning and memory) were evaluated in the novel object recognition
(NOR) and fear conditioning (for fear memory) tests. The experiments
were carried out on 6-month-old male WAG/Rij rats. The mothers of
the experimental group fed a MED, while the mothers of the control
group fed a control diet. The NOR test was used to assess episodic memory.
This test is based on innate exploratory (novelty preference) motivation,
which is usually reduced in depression. The conditioning of fear
memory is the classical Pavlovian defensive conditioned reflex,
manifested as freezing in response to negative reinforcement (electric
footshock). In the NOR test, in rats of the experimental group,
the novel object recognition index (a measure of episodic memory)
and the number of entries to the center of the arena (a measure
of exploratory motivation) were significantly higher compared to
the corresponding measures in the control group. However, no intergroup
differences were revealed in the manifestation of conditioned fear
memory (% of freezing responses) to a context and a sound cue. The
results indicate that the maternal MED improves episodic memory
in the NOR test but does not affect the conditioned fear memory
associated with a context and sound cue in the adult offspring of
WAG/Rij rats.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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