Comparison of the Effect of the Antidepressants Imipramine and Fluoxetine on the Sleep–Wake Cycle and Characteristics of Sleep Spindles in Wag/Rij Rats with Absence Epilepsy and Comorbid Depression
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引用次数: 0
Abstract
WAG/Rij rats are a valid model of absence epilepsy and comorbid
depression. We have previously shown that WAG/Rij rats have disturbances
in the sleep–wake cycle and changes in the characteristics of sleep
spindles. A negative correlation was also found between the number
of spike-wave discharges (SWD) and the duration of rapid eye movement
(REM) sleep. Clinical evidence suggests that the traditional antidepressants
imipramine and fluoxetine are effective in suppressing symptoms
of depression, but may have a negative impact on the sleep–wake
cycle and comorbid epilepsy in patients. Our previous studies in
WAG/Rij rats showed that imipramine, when administered chronically, increases
the number of SWDs, while fluoxetine at the same dose reduces their
number, although both antidepressants have a pronounced antidepressant
effect. Comparison of the effects of the antidepressants imipramine
and fluoxetine on the sleep–wake cycle and sleep spindles in WAG/Rij
rats remains unstudied. The purpose of this work is to find out:
(1) what effects do imipramine and fluoxetine have on the sleep–wake
cycle and the characteristics of sleep spindles in WAG/Rij rats
and (2) whether there are differences in their effects. To achieve
this goal, the characteristics of the sleep–wake cycle and sleep
spindles were compared in WAG/Rij rats after chronic administration
of antidepressants and saline and in non-epileptic Wistar rats.
Administration of imipramine led to a significant decrease in the duration
of REM sleep. The administration of imipramine, compared with fluoxetine,
also increased the latency of the transition to sleep and the transition
to REM sleep. Sleep spindle amplitude was significantly increased
by both antidepressants. However, the spectral power density of
“slow” and “medium” spindles, which predominate in WAG/Rij rats
compared to Wistar rats, was significantly higher after administration
of imipramine than fluoxetine. The results suggest that imipramine
causes greater negative changes in the sleep–wake cycle and sleep
spindles than fluoxetine. Studies in the WAG/Rij rat model indicate
that fluoxetine is more preferable antidepressant for the treatment
of depressive disorders comorbid with absence epilepsy, since it
does not cause a significant deterioration in sleep quality. These
results are consistent with clinical data.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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