76 Bioaerosol exposure in Norwegian waste sorting

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals Of Work Exposures and Health Pub Date : 2024-06-27 DOI:10.1093/annweh/wxae035.032

Elke Eriksen, Pål Graff, Anne Straumfors, Anani Afanou, Anne Mette Madsen, Alexander Eiler

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Abstract

Occupational exposure during handling and sorting of waste has previously been identified as causative agent for occupational disease. New work operations and technological progress facilitate the waste sorting industry with means to reach global sustainability goals, however, generate unknown work-exposure scenarios. Full-shift personal work air samples were collected to investigate levels of infectious and non-infectious microbial components in bioaerosols and to study the potential of organic dust to elicit an immune response in vitro (TLR activation cell model) and in vivo (plasma biomarkers). Large variation in assessed exposure measurements between and within WSP, as well as between seasons was identified. Dust levels were generally below the current Norwegian OEL (5mg/m3), however contained substantial levels of endotoxins, fungal particles, and microbial agents with immunostimulatory potential. Viable microorganisms in the inhalable fraction were dominated by fungi in the genus Aspergillus and bacteria in the genus Bacillus and Staphylococcus. The samples contained a substantial fraction of risk group 2 human pathogens. Thirty per cent of the organic dust samples elicited TLR activation in vitro. Monocyte levels, plasma levels of IL-1RA, IL-18 and TNFα as well as symptom prevalence of respiratory and general symptoms were higher among exposed waste workers compared to an unexposed control group. The present study indicates that Norwegian waste workers are potentially exposed to relatively high levels of microbial agents that may cause adverse health effects in susceptible individuals.

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76 挪威废物分拣中的生物气溶胶接触

废物处理和分类过程中的职业接触曾被确认为职业病的致病因素。新的工作操作和技术进步为垃圾分类行业提供了实现全球可持续发展目标的手段，但也产生了未知的工作接触情景。收集了全班个人工作空气样本，以调查生物气溶胶中传染性和非传染性微生物成分的水平，并研究有机粉尘在体外（TLR 激活细胞模型）和体内（血浆生物标志物）引起免疫反应的潜力。研究发现，在世界空间站之间、内部以及季节之间，经评估的暴露测量值存在很大差异。粉尘水平一般低于挪威现行的 OEL（5 毫克/立方米），但含有大量内毒素、真菌颗粒和具有免疫刺激潜力的微生物制剂。可吸入部分中可存活的微生物主要是曲霉属真菌以及芽孢杆菌和葡萄球菌属细菌。样本中含有大量第 2 组人类病原体。30% 的有机粉尘样本在体外诱发了 TLR 激活。与未接触有机粉尘的对照组相比，接触有机粉尘的工人的单核细胞水平、血浆中 IL-1RA、IL-18 和 TNFα 的水平以及呼吸道症状和全身症状的发生率均较高。本研究表明，挪威废物处理工人有可能接触到较高水平的微生物制剂，这些微生物制剂可能会对易感人群的健康造成不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.60

自引率

19.20%

发文量

期刊介绍： About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.