Global Dynamics of a Kawasaki Disease Vascular Endothelial Cell Injury Model with Backward Bifurcation and Hopf Bifurcation

Abstract

Kawasaki disease (KD) is an acute, febrile, systemic vasculitis that mainly affects children under five years of age. In this paper, we propose and study a class of 5-dimensional ordinary differential equation model describing the vascular endothelial cell injury in the lesion area of KD. This model exhibits forward/backward bifurcation. It is shown that the vascular injury-free equilibrium is locally asymptotically stable if the basic reproduction number R₀ < 1. Further, we obtain two types of suffcient conditions for the global asymptotic stability of the vascular injury-free equilibrium, which can be applied to both the forward and backward bifurcation cases. In addition, the local and global asymptotic stability of the vascular injury equilibria and the presence of Hopf bifurcation are studied. It is also shown that the model is permanent if the basic reproduction number R₀ > 1, and some explicit analytic expressions of ultimate lower bounds of the solutions of the model are given. Our results suggest that the control of vascular injury in the lesion area of KD is not only correlated with the basic reproduction number R₀, but also with the growth rate of normal vascular endothelial cells promoted by the vascular endothelial growth factor.