Experimental application of polyvinyl alcohol-silica for small artificial vessels.

K Tamura, H Mizuno, K Okada, H Katoh, S Hitomi, T Teramatsu, Y Shimizu, T Hino
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引用次数: 3

Abstract

Polyvinyl alcohol-silica (PVA-SiO2) composite and heparinized PVA-SiO2 were examined in vitro and in vivo as materials to coat artificial vessels to be used for the replacement of small arteries. PVA-SiO2 was observed to prolong coagulation time and on heparinized PVA-SiO2 surfaces no blood coagulation was noticed after a period of two days using the Lee-White and plasma recalcification methods. After placing non-coated and coated surfaces in contact with blood components in vitro and in vivo, the degree of blood component adhesion was greater in non-coated woven Dacron than in PVA-SiO2 coated Dacron. The degree of adhesion was even less in heparinized PVA-SiO2 coated Dacron. Furthermore, artificial vessels made of these 3 types of materials were used to replace parts of the canine abdominal aorta and were removed one and a half years later. Patency rates were as follows: non-coated 2/7, PVA-SiO2-coated 4/7, heparinized PVA-SiO2-coated 8/12. The inner surfaces of these prostheses were observed with light microscopy and scanning electron microscopy. Intima formation was thinner on the PVA-SiO2 composite surfaces than on the control surfaces. Heparin acted as a local anticoagulant and PVA-SiO2 limited intima formation. This report showed that PVA-SiO2 composite coated surfaces can be effective for small artery replacement due to good tissue affinity and anticoagulability.

聚乙烯醇-二氧化硅在小型人工血管中的实验应用。
在体外和体内研究了聚乙烯醇-二氧化硅(PVA-SiO2)复合材料和肝素化PVA-SiO2作为小动脉替代人工血管的包被材料。采用Lee-White法和血浆再钙化法,观察到PVA-SiO2可延长凝血时间,在肝素化的PVA-SiO2表面,2天后无凝血现象。在体外和体内实验中,将未涂层和涂层表面与血液成分接触后,未涂层的编织涤纶与血液成分的粘附程度大于PVA-SiO2涂层的编织涤纶。肝素化PVA-SiO2涂层涤纶的粘附程度更低。此外,用这三种材料制成的人工血管代替部分犬腹主动脉,并在一年半后切除。通畅率如下:未包被2/7,pva - sio2包被4/7,肝素化pva - sio2包被8/12。采用光镜和扫描电镜观察假体的内表面。PVA-SiO2复合表面的内膜形成比对照表面薄。肝素作为局部抗凝剂和PVA-SiO2限制内膜形成。该报告表明,PVA-SiO2复合涂层表面具有良好的组织亲和性和抗凝血性,可有效用于小动脉置换术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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