Methacrylic acid grafted inulin and carboxymethyl cellulose as additives in the development of pH sensitive hydrogel matrix for colon targeting

IF 3.8 4区工程技术 Q2 CHEMISTRY, APPLIED

Journal of Vinyl & Additive Technology Pub Date : 2024-07-01 DOI:10.1002/vnl.22133

Pallobi Dutta, Kaushik Mukherjee, Tapan Kumar Giri

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引用次数: 0

Abstract

Compression-coated matrix tablets were developed to target budesonide (BUD) in the colonic region using methacrylic acid (MAA) grafted inulin (INU) and carboxymethyl cellulose (CMC). INU was grafted with MAA to impart anionic characteristics to the gum, making it feasible to form a hydrogel by cross-linking with calcium gluconate (CG). The core matrix made up of MAA-g-INU alone disintegrated within 30 min and the core matrix made up of CMC alone completely released BUD within 6 h. The combination of MAA-g-INU and CMC produced a rigid matrix, which was able to completely release BUD after 7 h. Compression coating of the core tablets with MAA-g-INU and CMC did not release BUD in the first 4 h, and complete BUD release took place in the next 4 h. Compression coating led to the formation of a rigid and viscous gel layer outside the core matrices, which hindered BUD release. We conclude that compression coating with CG cross-linked CMC and MAA-g-INU could be used as a matrix for colonic delivery of drugs.

Highlights

Compression coated matrices were developed for colonic delivery of BUD.
The matrix retained drug release up to 4 h in upper gastrointestinal tract (GIT).
The matrix exhibited complete drug release in the next 4 h in the colon.

Abstract Image

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将甲基丙烯酸接枝菊粉和羧甲基纤维素作为添加剂，开发用于结肠靶向的 pH 值敏感水凝胶基质

利用甲基丙烯酸（MAA）接枝菊粉（INU）和羧甲基纤维素（CMC），开发了针对布地奈德（BUD）结肠区域的压缩包衣基质片剂。INU 与 MAA 接枝后可赋予树胶阴离子特性，从而可通过与葡萄糖酸钙 (CG) 交联形成水凝胶。由 MAA-g-INU 单独组成的核心基质在 30 分钟内崩解，由 CMC 单独组成的核心基质在 6 小时内完全释放 BUD。用 MAA-g-INU 和 CMC 对片芯进行压缩包衣后，在最初的 4 小时内未释放出 BUD，而在接下来的 4 小时内 BUD 被完全释放。我们的结论是，用 CG 交联 CMC 和 MAA-g-INU 进行压缩包衣可用作结肠给药的基质。该基质在上消化道（GIT）中的药物释放时间长达 4 小时。该基质在结肠中接下来的 4 小时内表现出完全的药物释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vinyl & Additive Technology 工程技术-材料科学：纺织

CiteScore

5.40

自引率

14.80%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Vinyl and Additive Technology is a peer-reviewed technical publication for new work in the fields of polymer modifiers and additives, vinyl polymers and selected review papers. Over half of all papers in JVAT are based on technology of additives and modifiers for all classes of polymers: thermoset polymers and both condensation and addition thermoplastics. Papers on vinyl technology include PVC additives.