Tyng‐Yuan Jang, Batbold Batsaikhan, Yo‐Chia Chen, Chia‐Yen Dai
{"title":"Hepatitis B surface antigen loss in chronic hepatitis B patients with low‐viral‐load","authors":"Tyng‐Yuan Jang, Batbold Batsaikhan, Yo‐Chia Chen, Chia‐Yen Dai","doi":"10.1111/jgh.16667","DOIUrl":null,"url":null,"abstract":"Background and AimAmong low viral load (DNA of hepatitis B virus (HBV) was < 2000 IU/mL), the factor of the loss of hepatitis B surface antigen (HBsAg) remained elusive.MethodsThe retrospective study recruited patients with chronic hepatitis B (CHB) who were negative low for hepatitis B e‐antigen (HBeAg), had a low viral load, and experienced HBsAg loss during follow‐up. CHB patients with low‐viral load but without consequent HBsAg loss were also enrolled at the ratio of 1:4. The factors contributing to HBsAg loss were analyzed.ResultsA total of 80 patients were recruited for the current study, with a mean age of 63.9 years and 61.3% being male. Among them, 62.5% patients (50/80) were treated with potent nucleoside/nucleotide analogues (NAs) during the follow‐up period. Additionally, 12.5% patients (10/80) had a prior history of NAs treatment before enrolment. During the follow‐up, HBsAg loss occurred in 17 patients (21.3%). Compared with patients without HBsAg loss, those with HBsAg loss were younger (57.9 years <jats:italic>vs</jats:italic> 65.5 years; <jats:italic>P</jats:italic> = 0.01), had lower HBV DNA levels (1.3 log<jats:sub>10</jats:sub> IU/mL <jats:italic>vs</jats:italic> 2.3 log<jats:sub>10</jats:sub> IU/mL; <jats:italic>P</jats:italic> = 0.003), and higher proportion of prior NAs‐treated history. Logistic regression analysis revealed that the factors associated with factors associated with HBsAg loss were age < 60 years (OR/CI: 3.95/1.15–13.60, <jats:italic>P</jats:italic> = 0.03), prior NAs‐treated history (OR/CI: 7.59/1.42–40.51, <jats:italic>P</jats:italic> = 0.01) and current NAs‐treated (OR/CI: 0.19/0.05–0.71, <jats:italic>P</jats:italic> = 0.01).ConclusionsIn the study, older age and prior NAs were positively associated with HBsAg loss, and current NAs was negatively associated with HBsAg loss. Additionally, some patients experienced HBsAg loss during the NAs therapy.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Gastroenterology and Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jgh.16667","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and AimAmong low viral load (DNA of hepatitis B virus (HBV) was < 2000 IU/mL), the factor of the loss of hepatitis B surface antigen (HBsAg) remained elusive.MethodsThe retrospective study recruited patients with chronic hepatitis B (CHB) who were negative low for hepatitis B e‐antigen (HBeAg), had a low viral load, and experienced HBsAg loss during follow‐up. CHB patients with low‐viral load but without consequent HBsAg loss were also enrolled at the ratio of 1:4. The factors contributing to HBsAg loss were analyzed.ResultsA total of 80 patients were recruited for the current study, with a mean age of 63.9 years and 61.3% being male. Among them, 62.5% patients (50/80) were treated with potent nucleoside/nucleotide analogues (NAs) during the follow‐up period. Additionally, 12.5% patients (10/80) had a prior history of NAs treatment before enrolment. During the follow‐up, HBsAg loss occurred in 17 patients (21.3%). Compared with patients without HBsAg loss, those with HBsAg loss were younger (57.9 years vs 65.5 years; P = 0.01), had lower HBV DNA levels (1.3 log10 IU/mL vs 2.3 log10 IU/mL; P = 0.003), and higher proportion of prior NAs‐treated history. Logistic regression analysis revealed that the factors associated with factors associated with HBsAg loss were age < 60 years (OR/CI: 3.95/1.15–13.60, P = 0.03), prior NAs‐treated history (OR/CI: 7.59/1.42–40.51, P = 0.01) and current NAs‐treated (OR/CI: 0.19/0.05–0.71, P = 0.01).ConclusionsIn the study, older age and prior NAs were positively associated with HBsAg loss, and current NAs was negatively associated with HBsAg loss. Additionally, some patients experienced HBsAg loss during the NAs therapy.
期刊介绍:
Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.