Fe3O4@SiO2-APA-Amide/Imid-CuCl2 nanocomposite as an efficient and reusable nanocatalyst for ecofriendly synthesis of 1,2,3-triazole derivatives

Abstract

In this methodology, a nanomagnetic copper catalyst prepared via the immobilization of CuCl₂ on the surface of Fe₃O₄@SiO₂-APA-Amide/Imid ligand and its structure identified by several spectroscopic techniques including XRD, FT-IR, VSM, SEM, TEM, ICP-OES, TGA, EDX and elemental mapping analysis. This Fe₃O₄@SiO₂-APA-Amide/Imid-CuCl₂ nanomaterial can catalyze the preparation of 1,2,3-triazole derivatives through reactions of alkyne derivatives with NaN₃ and aryl halides under ecofriendly conditions. It is noteworthy that the 1,2,3-triazole products were obtained with high yields when 2-phenylthiirane was used instead of aryl halides. In this research, one-pot three-component reactions were successfully performed in water, and the corresponding triazole products were obtained with high to excellent yields. After the end of the reaction, the Fe₃O₄@SiO₂-APA-Amide/Imid-CuCl₂ catalyst was recovered by magnetic separation and reused for 8 runs with a constant efficiency.

Graphical abstract