{"title":"Enhancement of induction heating capability of bioactive SiO2–CaO–Na2O–P2O5 glass-ceramics by selective substitution with magnetite nanoparticles","authors":"Nitu, Rushikesh Fopase, Lalit Mohan Pandey, Jyoti Prasad Borah and Ananthakrishnan Srinivasan","doi":"10.1088/1748-605x/ad51c0","DOIUrl":null,"url":null,"abstract":"Magnetic bioactive glass-ceramics with compositions of 37SiO2–24.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCS), 45SiO2–16.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCC) and 45SiO2–24.5CaO–16.5Na2O–6P2O5–8Fe3O4 (MGCN) were synthesized by sol–gel route. These compositions were derived by substituting 8 wt.% magnetite (Fe3O4) nanoparticles for SiO2, CaO and Na2O, respectively, in the bioactive glass-ceramic of composition 45SiO2–24.5CaO–24.5Na2O–6P2O5. The sol–gel derived powders were heat treated at 550 °C for 1 h to ensure optimal amounts of magnetite, combeite and sodium nitrate phases. All the heat treated samples were found to be magnetic, bioactive and non-toxic to MG-63 osteoblast cells. However, the induction heating response of MGCC was better than that of MGCS and MGCN. Notably, MGCC outperformed the commercially available ferrofluid FluidMag-CT, thereby establishing itself as a superior thermoseed for magnetic hyperthermia treatment of cancer.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1748-605x/ad51c0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Magnetic bioactive glass-ceramics with compositions of 37SiO2–24.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCS), 45SiO2–16.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCC) and 45SiO2–24.5CaO–16.5Na2O–6P2O5–8Fe3O4 (MGCN) were synthesized by sol–gel route. These compositions were derived by substituting 8 wt.% magnetite (Fe3O4) nanoparticles for SiO2, CaO and Na2O, respectively, in the bioactive glass-ceramic of composition 45SiO2–24.5CaO–24.5Na2O–6P2O5. The sol–gel derived powders were heat treated at 550 °C for 1 h to ensure optimal amounts of magnetite, combeite and sodium nitrate phases. All the heat treated samples were found to be magnetic, bioactive and non-toxic to MG-63 osteoblast cells. However, the induction heating response of MGCC was better than that of MGCS and MGCN. Notably, MGCC outperformed the commercially available ferrofluid FluidMag-CT, thereby establishing itself as a superior thermoseed for magnetic hyperthermia treatment of cancer.
期刊介绍:
The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare.
Typical areas of interest include (but are not limited to):
-Synthesis/characterization of biomedical materials-
Nature-inspired synthesis/biomineralization of biomedical materials-
In vitro/in vivo performance of biomedical materials-
Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning-
Microfluidic systems (including disease models): fabrication, testing & translational applications-
Tissue engineering/regenerative medicine-
Interaction of molecules/cells with materials-
Effects of biomaterials on stem cell behaviour-
Growth factors/genes/cells incorporated into biomedical materials-
Biophysical cues/biocompatibility pathways in biomedical materials performance-
Clinical applications of biomedical materials for cell therapies in disease (cancer etc)-
Nanomedicine, nanotoxicology and nanopathology-
Pharmacokinetic considerations in drug delivery systems-
Risks of contrast media in imaging systems-
Biosafety aspects of gene delivery agents-
Preclinical and clinical performance of implantable biomedical materials-
Translational and regulatory matters