Enhancement of induction heating capability of bioactive SiO2–CaO–Na2O–P2O5 glass-ceramics by selective substitution with magnetite nanoparticles

IF 3.9 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Nitu, Rushikesh Fopase, Lalit Mohan Pandey, Jyoti Prasad Borah and Ananthakrishnan Srinivasan
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引用次数: 0

Abstract

Magnetic bioactive glass-ceramics with compositions of 37SiO2–24.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCS), 45SiO2–16.5CaO–24.5Na2O–6P2O5–8Fe3O4 (MGCC) and 45SiO2–24.5CaO–16.5Na2O–6P2O5–8Fe3O4 (MGCN) were synthesized by sol–gel route. These compositions were derived by substituting 8 wt.% magnetite (Fe3O4) nanoparticles for SiO2, CaO and Na2O, respectively, in the bioactive glass-ceramic of composition 45SiO2–24.5CaO–24.5Na2O–6P2O5. The sol–gel derived powders were heat treated at 550 °C for 1 h to ensure optimal amounts of magnetite, combeite and sodium nitrate phases. All the heat treated samples were found to be magnetic, bioactive and non-toxic to MG-63 osteoblast cells. However, the induction heating response of MGCC was better than that of MGCS and MGCN. Notably, MGCC outperformed the commercially available ferrofluid FluidMag-CT, thereby establishing itself as a superior thermoseed for magnetic hyperthermia treatment of cancer.
通过选择性替代磁铁矿纳米颗粒提高生物活性 SiO2-CaO-Na2O-P2O5 玻璃陶瓷的感应加热能力
通过溶胶-凝胶路线合成了成分为 37SiO2-24.5CaO-24.5Na2O-6P2O5-8Fe3O4 (MGCS)、45SiO2-16.5CaO-24.5Na2O-6P2O5-8Fe3O4 (MGCC) 和 45SiO2-24.5CaO-16.5Na2O-6P2O5-8Fe3O4 (MGCN) 的磁性生物活性玻璃陶瓷。这些成分是通过在成分为 45SiO2-24.5CaO-24.5Na2O-6P2O5 的生物活性玻璃陶瓷中分别用 8 重量%的磁铁矿(Fe3O4)纳米颗粒代替 SiO2、CaO 和 Na2O 而得到的。溶胶-凝胶法制备的粉末在 550 °C 下热处理 1 小时,以确保磁铁矿、泡沸石和硝酸钠相的最佳含量。所有热处理样品都具有磁性、生物活性,并且对 MG-63 成骨细胞无毒。不过,MGCC 的诱导加热反应优于 MGCS 和 MGCN。值得注意的是,MGCC 的性能优于市售的铁流体 FluidMag-CT,从而使其成为磁性热疗治疗癌症的优质热源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical materials
Biomedical materials 工程技术-材料科学:生物材料
CiteScore
6.70
自引率
7.50%
发文量
294
审稿时长
3 months
期刊介绍: The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters
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