The Software System of a Dedicated Brain PET Scanner Using Dual-Ended Readout Detectors With High-DOI Resolution

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jiamin Liu;Ning Ren;Tianyi Zeng;Zhonghua Kuang;Qiyang Zhang;Xiaohui Wang;Zheng Liu;Hairong Zheng;Dong Liang;Yongfeng Yang;Zhanli Hu
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Abstract

A dedicated brain positron emission tomography (PET) scanner can achieve higher-spatial resolution, sensitivity, and cost-effectiveness than whole-body PET scanners. In this study, we present the software system for a dedicated brain PET scanner, encompassing data acquisition, detector calibration, sinogram generation, imaging reconstruction, and data correction. The dedicated brain PET scanner features 224 depth-encoding detectors, each with a depth of interaction (DOI) resolution of approximately 2 mm. The electronics and data acquisition system of the scanner can be configured in different modes for detector calibration or image acquisition. Procedures for obtaining detector calibration parameters, including crystal look-up tables (LUTs), crystal depth-of-interaction LUTs, crystal energy, and timing calibration parameters, were developed. A novel virtual crystal-based sinogram generation method was developed to reduce sinogram size while preserving positioning accuracy. We also introduced a graphics processing unit-accelerated ordered subset expectation maximization imaging reconstruction method. The spatial resolution of the scanner was assessed using a point source at both the center and 1/4 axial field of view with varying radial offsets. We measured singles and prompt count rates at different activities using a monkey-sized phantom. Furthermore, we conducted scans on a 3-D Hoffman brain phantom and a rabbit, demonstrated the imaging capabilities of the PET scanner.
使用高分辨率双端读出探测器的专用脑 PET 扫描仪软件系统
与全身正电子发射计算机断层扫描(PET)相比,专用脑正电子发射计算机断层扫描(PET)可实现更高的空间分辨率、灵敏度和成本效益。在本研究中,我们介绍了专用脑正电子发射计算机断层扫描仪的软件系统,包括数据采集、探测器校准、正弦曲线生成、成像重建和数据校正。专用脑 PET 扫描仪配备 224 个深度编码探测器,每个探测器的交互深度(DOI)分辨率约为 2 毫米。扫描仪的电子设备和数据采集系统可配置为不同模式,用于探测器校准或图像采集。开发了获取探测器校准参数的程序,包括晶体查找表(LUT)、晶体相互作用深度 LUT、晶体能量和定时校准参数。我们还开发了一种新颖的基于虚拟晶体的正弦曲线生成方法,可在保持定位精度的同时缩小正弦曲线的尺寸。我们还引入了图形处理单元加速有序子集期望最大化成像重建方法。我们在中心视场和 1/4 轴向视场使用不同径向偏移的点源评估了扫描仪的空间分辨率。我们使用一个猴子大小的模型测量了不同活动状态下的单次和即时计数率。此外,我们还对三维霍夫曼脑模型和兔子进行了扫描,展示了 PET 扫描仪的成像能力。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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