Assessment of alendronate and dietary treatment in the management of feline idiopathic ionised hypercalcaemia and ionised hypercalcaemia associated with chronic kidney disease: 29 cases (2016-2022)

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2024-07-04 DOI:10.1111/jsap.13755

U. Rzeszutek, F. Allerton, C. Au, I. Bras, A. Briggs, H. Broome, T. Gamston, S. Parton, J. Raj, G. M. Rossell, O. Russell, T. Sparks, J. Bazelle

{"title":"Assessment of alendronate and dietary treatment in the management of feline idiopathic ionised hypercalcaemia and ionised hypercalcaemia associated with chronic kidney disease: 29 cases (2016-2022)","authors":"U. Rzeszutek, F. Allerton, C. Au, I. Bras, A. Briggs, H. Broome, T. Gamston, S. Parton, J. Raj, G. M. Rossell, O. Russell, T. Sparks, J. Bazelle","doi":"10.1111/jsap.13755","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This retrospective cohort multicentre study aimed to characterise the signalment, clinicopathologic data, complications and the association between treatment and outcome (the reduction in ionised calcium concentration) in cats with idiopathic or chronic kidney disease-associated ionised hypercalcaemia managed with alendronate and standard treatment or standard treatment alone, and to compare the outcome between the two groups.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Medical records for cats diagnosed with idiopathic or chronic kidney disease-associated ionised hypercalcaemia were retrospectively reviewed. Cats treated with alendronate and standard treatment were assigned to the alendronate group and cats treated with standard treatment alone were assigned to the control group. The standard treatment was defined as dietary modification and/or monitoring of ionised calcium concentrations and management of complications secondary to hypercalcaemia. The follow-up period was selected as 6 months.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Twenty-nine cats were enrolled in the study. Nine cats were included in the control group and 20 cats in the alendronate group. A significant reduction in serum ionised calcium was observed in both groups between the baseline and the follow-up visit; however, this reduction did not differ significantly between both groups (the mean change in the ionised calcium concentration in alendronate and control group was −0.18 and −0.17, respectively). Suspected bisphosphate-related osteonecrosis of the jaw was reported in one cat receiving alendronate.</p>\n </section>\n \n <section>\n \n <h3> Clinical Significance</h3>\n \n <p>In this study, similar reduction in serum ionised calcium concentration was observed in cats with ionised hypercalcaemia treated with diet alone and in cats treated with diet and alendronate. These results should be interpreted with caution, as the study was underpowered for meaningful statistical comparison. Cats receiving alendronate should be monitored for the development of adverse reactions, including osteonecrosis of the jaw.</p>\n </section>\n </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Small Animal Practice","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jsap.13755","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This retrospective cohort multicentre study aimed to characterise the signalment, clinicopathologic data, complications and the association between treatment and outcome (the reduction in ionised calcium concentration) in cats with idiopathic or chronic kidney disease-associated ionised hypercalcaemia managed with alendronate and standard treatment or standard treatment alone, and to compare the outcome between the two groups.

Materials and Methods

Medical records for cats diagnosed with idiopathic or chronic kidney disease-associated ionised hypercalcaemia were retrospectively reviewed. Cats treated with alendronate and standard treatment were assigned to the alendronate group and cats treated with standard treatment alone were assigned to the control group. The standard treatment was defined as dietary modification and/or monitoring of ionised calcium concentrations and management of complications secondary to hypercalcaemia. The follow-up period was selected as 6 months.

Results

Twenty-nine cats were enrolled in the study. Nine cats were included in the control group and 20 cats in the alendronate group. A significant reduction in serum ionised calcium was observed in both groups between the baseline and the follow-up visit; however, this reduction did not differ significantly between both groups (the mean change in the ionised calcium concentration in alendronate and control group was −0.18 and −0.17, respectively). Suspected bisphosphate-related osteonecrosis of the jaw was reported in one cat receiving alendronate.

Clinical Significance

In this study, similar reduction in serum ionised calcium concentration was observed in cats with ionised hypercalcaemia treated with diet alone and in cats treated with diet and alendronate. These results should be interpreted with caution, as the study was underpowered for meaningful statistical comparison. Cats receiving alendronate should be monitored for the development of adverse reactions, including osteonecrosis of the jaw.

查看原文本刊更多论文

评估阿仑膦酸钠和饮食治疗在治疗猫特发性离子型高钙血症和与慢性肾病相关的离子型高钙血症中的应用：29例（2016-2022年）。

研究目的这项回顾性队列多中心研究旨在描述特发性或慢性肾脏病相关离子型高钙血症猫咪的信号、临床病理数据、并发症以及治疗与结果（离子钙浓度的降低）之间的关联，并比较两组之间的结果：回顾性审查被诊断为特发性或慢性肾病相关离子化高钙血症的猫的病历。将接受阿仑膦酸钠和标准治疗的猫归入阿仑膦酸钠组，将只接受标准治疗的猫归入对照组。标准治疗的定义是调整饮食和/或监测离子钙浓度，并处理继发于高钙血症的并发症。随访期为 6 个月：结果：29 只猫参加了研究。结果：29 只猫参加了研究，其中 9 只为对照组，20 只为阿仑膦酸钠组。从基线到随访期间，两组的血清离子钙均有明显下降，但两组的下降幅度并无明显差异（阿仑膦酸钠组和对照组的离子钙浓度平均变化分别为-0.18和-0.17）。据报道，一只猫在接受阿仑膦酸钠治疗后出现了疑似与双磷酸盐相关的颌骨坏死：在这项研究中，单独使用饮食治疗离子型高钙血症的猫和使用饮食和阿仑膦酸钠治疗的猫的血清离子钙浓度降低情况相似。这些结果应谨慎解释，因为该研究的能力不足，无法进行有意义的统计比较。应监测接受阿仑膦酸钠治疗的猫是否出现不良反应，包括颌骨坏死。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association