Forensic age estimation by MRI of the knee - comparison of two classifications for ossification stages in a German population.

IF 2.2 3区 医学 Q1 MEDICINE, LEGAL
International Journal of Legal Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI:10.1007/s00414-024-03281-5
V Malokaj, Wernsing Mf, Kunz Sn, M Beer, Vogele Daniel
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引用次数: 0

Abstract

Aim and objectives: In forensic age estimation e.g. for judicial proceedings surpassed age thresholds can be legally relevant. To examine age related differences in skeletal development the recommendations by the Study Group on Forensic Age Diagnostics (AGFAD) are based on ionizing radiation (among others orthopantomograms, plain x-rays of the hand). Vieth et al. and Ottow et al. proposed MRI-classifications for the epiphyseal-diaphyseal fusion of the knee joint to define different age groups in healthy volunteers. The aim of the present study was to directly compare these two classifications in a large German patient population.

Materials and methods: MRI of the knee joint of 900 patients (405 female, 495 male) from 10 to 28 years of age were retrospectively analyzed. Acquired T1-weighted turbo spin-echo sequence (TSE) and T2-weighted sequence with fat suppression by turbo inversion recovery magnitude (TIRM) were analyzed for the two classifications. The different bony fusion stages of the two classifications were determined and the corresponding chronological ages assigned. Differences between the sexes were analyzed. Intra- and inter-observer agreements were determined using Cohen's kappa.

Results: With the classification of Ottow et al. it was possible to determine completion of the 18th and 21st year of life in both sexes. With the classification of Vieth et al. completion of the 18th year of life for female patients and the 14th and 21st year of life in both sexes could be determined. The intra- and inter-observer agreement levels were very good (κ > 0.82).

Conclusion: In the large German patient cohort of this study it was possible to determine the 18th year of life with for both sexes with the classification of Ottow et al. and for female patients with the classification of Vieth et al. It was also possible to determine the 21st year of life for all bones with the classification of Ottow et al. and for the distal femur with the classification of Vieth et al.

Abstract Image

通过膝关节核磁共振成像估算法医年龄--比较德国人群骨化阶段的两种分类方法。
目的和目标:在法医年龄估计中,例如在司法程序中,超过年龄阈值可能具有法律意义。为了检查与年龄有关的骨骼发育差异,法医年龄诊断研究小组(AGFAD)建议采用电离辐射(包括正位像、手部普通 X 光片)。Vieth 等人和 Ottow 等人提出了膝关节骨骺-骨骺融合的 MRI 分类,以界定健康志愿者的不同年龄组。本研究的目的是在大量德国患者中直接比较这两种分类方法:对 900 名 10 至 28 岁患者(405 名女性,495 名男性)的膝关节核磁共振成像进行了回顾性分析。对获得的 T1 加权涡轮自旋回波序列(TSE)和通过涡轮反转恢复幅度(TIRM)进行脂肪抑制的 T2 加权序列进行了两种分类分析。确定了两种分类的不同骨融合阶段,并分配了相应的年代年龄。对性别差异进行了分析。使用科恩卡帕(Cohen's kappa)确定观察者内部和观察者之间的一致性:结果:根据 Ottow 等人的分类方法,可以确定男女的第 18 岁和第 21 岁年龄。根据 Vieth 等人的分类方法,可以确定女性患者的第 18 岁和男性患者的第 14 岁和第 21 岁。观察者内部和观察者之间的一致性非常好(κ > 0.82):在这项研究的大型德国患者队列中,可以用 Ottow 等人的分类方法确定男女患者的第 18 岁寿命,用 Vieth 等人的分类方法确定女性患者的第 18 岁寿命,还可以用 Ottow 等人的分类方法确定所有骨骼的第 21 岁寿命,用 Vieth 等人的分类方法确定股骨远端的第 21 岁寿命。
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来源期刊
CiteScore
5.80
自引率
9.50%
发文量
165
审稿时长
1 months
期刊介绍: The International Journal of Legal Medicine aims to improve the scientific resources used in the elucidation of crime and related forensic applications at a high level of evidential proof. The journal offers review articles tracing development in specific areas, with up-to-date analysis; original articles discussing significant recent research results; case reports describing interesting and exceptional examples; population data; letters to the editors; and technical notes, which appear in a section originally created for rapid publication of data in the dynamic field of DNA analysis.
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