Clinical relevance of Staphylococcus saccharolyticus detection in human samples: a retrospective cohort study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI:10.1007/s15010-024-02334-6

Ricarda Michels, Cihan Papan, Sébastien Boutin, Farah Alhussein, Sören L Becker, Dennis Nurjadi, Katharina Last

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引用次数: 0

Abstract

Purpose: To characterize the clinical relevance of S. saccharolyticus and to identify criteria to distinguish between infection and contamination.

Methods: We retrospectively investigated clinical features of patients with S. saccharolyticus detection between June 2009 and July 2021. Based on six criteria, infection was considered likely for patients with a score from 3 to 6 points, infection was considered unlikely for patients with a score from 0 to 2 points. We performed group comparison and logistic regression to identify factors than are associated with likely infection. In addition, whole genome sequencing (WGS) of 22 isolates was performed.

Results: Of 93 patients in total, 44 were assigned to the group "infection likely" and 49 to the group "infection unlikely". Multiple regression analysis revealed "maximum body temperature during hospital stay" to have the strongest predictive effect on likely infection (adjusted odds ratio 4.40, 95% confidence interval 2.07-9.23). WGS revealed two different clades. Compared to isolates from clade A, isolates from clade B were more frequently associated with implanted medical devices (3/10 vs. 9/12, p = 0.046) and a shorter time to positivity (TTP) (4.5 vs. 3, p = 0.016). Both clades did neither differ significantly in terms of causing a likely infection (clade A 7/10 vs. clade B 5/12, p = 0.23) nor in median length of hospital stay (28 vs. 15.5 days, p = 0.083) and length of stay at the ICU (21 vs. 3.5 days, p = 0.14).

Conclusion: These findings indicate that S. saccharolyticus can cause clinically relevant infections. Differentiation between infection and contamination remains challenging.

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在人体样本中检测出糖溶性葡萄球菌的临床意义：一项回顾性队列研究。

目的：描述糖溶性沙雷菌的临床意义，并确定区分感染和污染的标准：我们回顾性调查了 2009 年 6 月至 2021 年 7 月期间检测出糖溶菌的患者的临床特征。根据六项标准，得分在 3 到 6 分之间的患者被认为可能感染，得分在 0 到 2 分之间的患者被认为不可能感染。我们进行了分组比较和逻辑回归，以确定与可能感染相关的因素。此外，我们还对 22 个分离株进行了全基因组测序（WGS）：结果：在总共 93 名患者中，44 人被归入 "可能感染 "组，49 人被归入 "不可能感染 "组。多元回归分析显示，"住院期间的最高体温 "对可能感染的预测效果最强（调整后的几率比为 4.40，95% 置信区间为 2.07-9.23）。WGS 发现了两个不同的支系。与 A 支系的分离株相比，B 支系的分离株更常与植入的医疗设备相关（3/10 对 9/12，p = 0.046），阳性时间（TTP）更短（4.5 对 3，p = 0.016）。两个支系在造成可能感染（A支系 7/10 对 B 支系 5/12，p = 0.23）、中位住院时间（28 对 15.5 天，p = 0.083）和重症监护室住院时间（21 对 3.5 天，p = 0.14）方面均无明显差异：这些研究结果表明，糖溶性沙雷氏菌可引起临床相关感染。结论：这些研究结果表明，糖溶性沙雷菌可引起临床相关感染，但区分感染和污染仍具有挑战性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.