Quantitative investigation of acute lesions created by ethanol infusion into the vein of Marshall.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart rhythm Pub Date : 2025-01-01 Epub Date: 2024-07-02 DOI:10.1016/j.hrthm.2024.06.054

Kaoru Okishige, Naohiko Kawaguchi, Takatoshi Shigeta, Yasuteru Yamauchi, Takeshi Sasaki, Takehiko Keida, Kaoru Tanno, Kenzo Hirao, Tetsuo Sasano

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引用次数: 0

Abstract

Background: Ethanol infusion into the vein of Marshall (EIVOM) has been performed as an adjunctive atrial fibrillation therapy. However, the time course change, quantitative lesion investigation, and effects on epicardial fat pads and fractionated atrial electrograms created by EIVOM have never been investigated.

Objective: This study aimed to perform a quantitative analysis of lesions created by EIVOM.

Methods: We created voltage maps using a 3-dimensional mapping system immediately before and 30 minutes and 60 minutes after performing EIVOM to study the time course change in the lesions. We compared differences in the average contact force value required for successful conduction block in the Marshall vein area of patients with and without EIVOM. We also investigated effects of EIVOM on the area of complex fractionated atrial electrograms before and after EIVOM. We measured the total epicardial fat pad volume before and after EIVOM by computed tomography.

Results: Voltage was significantly reduced after EIVOM, and there were significant differences in voltage reduction between the control status and 30 minutes and 60 minutes after EIVOM (P < .05). The average contact force value was significantly lower with vs without EIVOM (P < .05). The total epicardial fat volume and complex fractionated atrial electrogram area also significantly decreased after EIVOM (P < .05).

Conclusion: EIVOM provided significant therapeutic effects on the left atrial tissue perpetuating atrial fibrillation, which was demonstrated by a quantitative analysis.

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乙醇注入马歇尔静脉造成急性损伤的定量研究

背景：向马歇尔静脉（VOM）注入乙醇（EI）（EIVOM）已被用作心房颤动（AF）的辅助治疗。然而，有关 EIVOM 的时间进程变化、定量病变调查、对心外膜脂肪垫和分馏心房电图的影响等问题还从未进行过研究：本研究旨在对 EIVOM 造成的病变进行定量分析：方法：我们使用三维制图系统绘制了 EIVOM 术后立即、30 分钟和 60 分钟的电压图，以研究病变的时间进程变化。其中，我们比较了有 EIVOM 和没有 EIVOM 的患者在 VOM 区域成功传导阻滞所需的平均接触力 (CF) 值的差异。我们还研究了EIVOM对EIVOM前和EIVOM后连续分频心房电图（CFAE）区域的影响。我们使用计算机断层扫描测量了EIVOM前后心外膜脂肪垫的总体积：结果：EIVOM后电压明显降低，对照组、EIVOM后30分钟组和60分钟组的电压降低率存在明显差异（p）：定量分析结果表明，EIVOM对导致房颤的左心房组织具有明显的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.