Evaluation of sperm quality and male fertility: The use of molecular markers in boar sperm and seminal plasma

IF 2.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Reproduction Science Pub Date : 2024-10-01 DOI:10.1016/j.anireprosci.2024.107545

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引用次数: 0

Abstract

In pig production, the optimization of artificial insemination (AI) efficiency significantly relies on the accurate assessment of semen quality and fertility of boars. Traditional methods such as conventional seminogram techniques, although long-standing, exhibit limited sensitivity in predicting boar fertility, warranting the exploration of novel molecular markers. This review synthesizes the current knowledge on the utilization of molecular markers for semen quality evaluation and male fertility prediction in boars, providing an in-depth examination of molecular markers in this context. Specifically, the present work delves into the potential of OMICs technologies, encompassing genetic and genomic approaches, transcriptomics, proteomics, and metabolomics. A diverse array of molecular markers, including genomic regions associated with sperm quality and male fertility, chromatin integrity, mitochondrial DNA content, mRNA and non-coding RNA signatures, as well as proteins and metabolites in sperm and seminal plasma, are identified as promising molecular markers for fertility prediction in boars. Furthermore, the need of validating biomarkers and their practical implementation in AI centres is here emphasized. Addressing these considerations and integrating molecular markers within the swine breeding field holds the potential to enhance reproductive management practices and optimize productivity in boar breeding programs. This integration can significantly improve overall efficiency within the pig breeding industry.

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评估精子质量和男性生育能力：使用公猪精子和精浆中的分子标记。

在养猪生产中，人工授精（AI）效率的优化在很大程度上取决于对公猪精液质量和繁殖力的准确评估。传统方法（如传统精液图技术）虽然历史悠久，但在预测公猪繁殖力方面的灵敏度有限，因此需要探索新型分子标记。本综述综合了目前利用分子标记评价公猪精液质量和预测雄性繁殖力的知识，深入探讨了这方面的分子标记。具体来说，本研究深入探讨了 OMICs 技术的潜力，包括遗传和基因组学方法、转录组学、蛋白质组学和代谢组学。这些分子标记包括与精子质量和雄性繁殖力相关的基因组区域、染色质完整性、线粒体DNA含量、mRNA和非编码RNA特征，以及精子和精浆中的蛋白质和代谢物。此外，本文还强调了验证生物标记及其在人工授精中心实际应用的必要性。考虑到这些因素并将分子标记纳入猪育种领域，有可能加强公猪育种项目的繁殖管理实践并优化生产力。这种整合可大大提高养猪业的整体效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Reproduction Science 农林科学-奶制品与动物科学

CiteScore

4.50

自引率

9.10%

发文量

136

审稿时长

54 days

期刊介绍： Animal Reproduction Science publishes results from studies relating to reproduction and fertility in animals. This includes both fundamental research and applied studies, including management practices that increase our understanding of the biology and manipulation of reproduction. Manuscripts should go into depth in the mechanisms involved in the research reported, rather than a give a mere description of findings. The focus is on animals that are useful to humans including food- and fibre-producing; companion/recreational; captive; and endangered species including zoo animals, but excluding laboratory animals unless the results of the study provide new information that impacts the basic understanding of the biology or manipulation of reproduction. The journal''s scope includes the study of reproductive physiology and endocrinology, reproductive cycles, natural and artificial control of reproduction, preservation and use of gametes and embryos, pregnancy and parturition, infertility and sterility, diagnostic and therapeutic techniques. The Editorial Board of Animal Reproduction Science has decided not to publish papers in which there is an exclusive examination of the in vitro development of oocytes and embryos; however, there will be consideration of papers that include in vitro studies where the source of the oocytes and/or development of the embryos beyond the blastocyst stage is part of the experimental design.