Gland regeneration

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2024-07-02 DOI:10.1038/s41684-024-01400-8

Alexandra Le Bras

引用次数: 0

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腺体再生

对于患有口干症、斯约格伦综合征或头颈部癌症放疗副作用的患者来说，基于细胞的唾液腺生成疗法是一种前景广阔的未来疗法。在《细胞报告》（Cell Reports）中，研究人员利用条件性囊胚补体（CBC）技术，从小鼠的多能干细胞中生成了全功能唾液腺。鉴于CBC的基础是在一个空位上创造一个新器官，研究人员首先必须开发一种缺乏唾液腺的小鼠模型。在证明了Foxa2血统有助于小鼠唾液腺的发育以及Fgfr2对唾液腺原基的形成至关重要之后，研究人员创建了Foxa2驱动的Fgfr2基因敲除小鼠，这些小鼠显示出唾液腺缺失的表型。将小鼠供体多能干细胞注入小鼠胚泡可挽救这种表型，结果小鼠存活到成年，唾液腺大小正常，与对照小鼠相当。这些发现可为未来开发基于细胞的先进唾液腺再生疗法提供指导：Tanaka, J. et al. Cell Rep. 43, 114340 (2024)

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.