No causal associations of genetically predicted birth weight and life course BMI with thyroid function and diseases

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-07-02 DOI:10.1002/oby.24095

Xiaoqin Zhou, Weiqiang Ruan, Jing Li, Ting Wang, Huizhen Liu, Guiying Zhang

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引用次数: 0

Abstract

Objective

Observational studies have suggested associations of birth weight, childhood BMI, and adulthood BMI with thyroid function or diseases. However, the causal relationships remain unclear due to residual confounding inherent in conventional epidemiological studies.

Methods

We performed a two-sample Mendelian randomization (MR) study to investigate causal relationships of genetically predicted birth weight, childhood BMI, and adulthood BMI with a range of clinically relevant thyroid outcomes. Additionally, we conducted a reverse MR analysis on adulthood BMI. Data on exposures and outcomes were obtained from large-scale genome-wide association study meta-analyses predominantly composed of individuals of European ancestry.

Results

The MR analysis revealed no evidence of causal associations of birth weight or BMI at different life stages with thyrotropin (TSH) levels, hypothyroidism, hyperthyroidism, autoimmune thyroid disorders, or thyroid cancer. Contrarily, thyroid cancer demonstrated a significant causal relationship with increased adulthood BMI (β = 0.010, 95% CI: 0.006–0.015; p = 5.21 × 10⁻⁶).

Conclusions

Our comprehensive MR did not find causal links of birth weight, childhood BMI, or adulthood BMI with thyroid diseases but provided evidence that thyroid cancer may play a role in weight gain. Our research findings offer valuable insights into the intricate relationship between body weight and thyroid health throughout an individual's life.

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遗传预测的出生体重和生命过程中的体重指数与甲状腺功能和疾病没有因果关系。

目的：观察性研究表明，出生体重、儿童期体重指数和成年期体重指数与甲状腺功能或疾病有关。然而，由于传统流行病学研究中固有的残余混杂因素，其因果关系仍不明确：我们进行了一项双样本孟德尔随机化（MR）研究，以调查遗传预测的出生体重、儿童期体重指数和成年期体重指数与一系列临床相关甲状腺结果的因果关系。此外，我们还对成年后的体重指数进行了反向 MR 分析。有关暴露和结果的数据来自大规模的全基因组关联研究荟萃分析，主要由欧洲血统的个体组成：MR分析显示，没有证据表明不同生命阶段的出生体重或体重指数与促甲状腺激素（TSH）水平、甲状腺功能减退症、甲状腺功能亢进症、自身免疫性甲状腺疾病或甲状腺癌存在因果关系。与此相反，甲状腺癌与成年期体重指数的增加有显著的因果关系（β = 0.010，95% CI：0.006-0.015；P = 5.21 × 10-6）：我们的综合 MR 没有发现出生体重、儿童期 BMI 或成年期 BMI 与甲状腺疾病的因果关系，但提供了甲状腺癌可能在体重增加中发挥作用的证据。我们的研究结果为了解体重与甲状腺健康之间错综复杂的关系提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.