Pathophysiological role of histamine signaling and its implications in glioblastoma

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Poonam Yadav , Raghupathy Vengoji , Maneesh Jain , Surinder K. Batra , Nicole Shonka
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引用次数: 0

Abstract

Glioblastoma (GBM), an extremely aggressive and prevalent malignant brain tumor, remains a challenge to treat. Despite a multimodality treatment approach, GBM recurrence remains inevitable, particularly with the emergence of temozolomide (TMZ) resistance and limited treatment options. Surprisingly, previous studies show that a history of allergies, atopy, or asthma is inversely associated with GBM risk. Further, the electronic medical record at the University Hospital of Lausanne showed that the GBM patients taking antihistamine during treatment had better survival. Histamine is an essential neurotransmitter in the brain and plays a significant role in regulating sleep, hormonal balance, and cognitive functions. Elevated levels of histamine and increased histamine receptor expression have been found in different tumors and their microenvironments, including GBM. High histamine 1 receptor (HRH1) expression is inversely related to overall and progression-free survival in GBM patients, further emphasizing the role of histamine in disease progression. This review aims to provide insights into the challenges of GBM treatment, the role of histamine in GBM progression, and the rationale for considering antihistamines as targeted therapy. The review concludes by encouraging further investigation into antihistamine mechanisms and their impact on the tumor microenvironment.

组胺信号的病理生理学作用及其对胶质母细胞瘤的影响。
胶质母细胞瘤(GBM)是一种侵袭性极强、发病率极高的恶性脑肿瘤,其治疗仍是一项挑战。尽管采用了多模式治疗方法,但 GBM 复发仍不可避免,尤其是在出现替莫唑胺(TMZ)耐药性和治疗选择有限的情况下。令人惊讶的是,以往的研究表明,过敏史、过敏症或哮喘与 GBM 风险成反比。此外,洛桑大学医院的电子病历显示,在治疗期间服用抗组胺药的GBM患者存活率更高。组胺是大脑中一种重要的神经递质,在调节睡眠、荷尔蒙平衡和认知功能方面发挥着重要作用。组胺水平升高和组胺受体表达增加已被发现存在于不同的肿瘤及其微环境中,包括脑胶质瘤。组胺 1 受体(HRH1)的高表达与 GBM 患者的总生存期和无进展生存期成反比,这进一步强调了组胺在疾病进展中的作用。本综述旨在深入探讨 GBM 治疗面临的挑战、组胺在 GBM 进展中的作用以及考虑将抗组胺药作为靶向治疗的理由。综述最后鼓励进一步研究抗组胺机制及其对肿瘤微环境的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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