Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites.

Nanomedicine (London, England) Pub Date : 2024-07-14 Epub Date: 2024-07-02 DOI:10.1080/17435889.2024.2362611

Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Pavel Bradna, Adela Roubickova, Zdenek Krejcik, Jiri Klema, Pavel Rossner, Andrea Rossnerova

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Abstract

Aim: Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. Methods: Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. Results: We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. Conclusion: The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.

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人类在研磨牙科纳米复合材料过程中急性暴露于纳米粒子的转录组变化。

目的：目前，有关人类急性接触纳米粒子（NPs）的研究还很缺乏。我们的调查旨在模拟在牙科诊所或技师实验室中使用牙科纳米复合材料时释放出的 NPs 的真实世界急性吸入暴露。调查方法在吸入暴露前后处理女性志愿者的血液样本。分析转录组 mRNA 和 miRNA 表达的变化。结果在对纳米复合材料磨牙前后的参与者样本进行比较时，我们发现个体间差异很大，有 90 种 mRNA 和 4 种 miRNA 明显失调。结论结果表明，吸入的牙科 NPs 可能会对人体健康造成职业危害，氧化应激、类二十酸合成和细胞分裂相关过程的变化就表明了这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanomedicine (London, England)

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