Adam Thompson-Harvey, Madeline Pyle, Erin Harvey, Michael S Harris
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引用次数: 0
Abstract
Objective: To systematically review how audiometric data change over time in patients with Menière's disease (MD) undergoing non-ablative medical therapy.
Databases reviewed: Medline (via PubMed), Scopus, Web of Science, Cumulated Index to Nursing and Allied Health Literature (CINAHL), Google Scholar.
Methods: A systematic review and meta-analysis of the literature was performed. Adult patients undergoing non-ablative medical therapy and reported duration of disease or follow-up were included and pooled estimates of pure-tone average (PTA) were tabulated. Studies were excluded if they did not use established MD, did not have pure-tone average (PTA) audiometric data, underwent ear surgery or ablative therapies, and were systematic reviews or case reports.
Results: Out of 198 articles meeting full eligibility, 13 studies, involving 950 patients with MD, were included in the review and further analyzed. No effect on progression of PTA from initial diagnosis was seen between the different medical therapies within 2 years of non-ablative medical treatment. There was a significant worsening of PTA after 2 year, regardless of treatment used. High levels of heterogeneity among studies were noted up to 6 months from diagnosis ( I2 = 79%), likely reflecting differences in patient characteristics, treatment regimens, and study design. Overall, the risk of bias was low for the majority of included studies.
Conclusions: Patients diagnosed with MD who are undergoing non-ablative medical therapy should be counseled on the likelihood of worsening of hearing loss over the course of the disease despite elected treatment.
目的：系统回顾接受非烧蚀疗法的梅尼埃病患者的听力数据随时间的变化情况：所查阅的数据库：Medline（通过 PubMed）、Scopus、Web of Science、Cumulated Index to Nursing and Allied Health Literature (CINAHL)、Google Scholar：方法：对文献进行系统回顾和荟萃分析。纳入了接受非烧蚀药物治疗的成年患者，并报告了病程或随访时间，同时将纯音平均值（PTA）的汇总估计值制成表格。如果研究未使用已确定的 MD、没有纯音平均值（PTA）测听数据、接受过耳部手术或烧蚀疗法、系统综述或病例报告，则将其排除在外：在符合全部资格的 198 篇文章中，有 13 项研究（涉及 950 名 MD 患者）被纳入综述并进行了进一步分析。在非烧蚀药物治疗后的两年内，不同的药物疗法对PTA的进展没有影响。无论采用哪种疗法，PTA 在 2 年后都会明显恶化。在诊断后6个月内，不同研究之间存在高度异质性（I2 = 79%），这可能反映了患者特征、治疗方案和研究设计的差异。总体而言，大部分纳入研究的偏倚风险较低：结论：对于确诊为MD并正在接受非烧蚀药物治疗的患者，应告知他们尽管选择了治疗方案，听力损失仍有可能在病程中恶化。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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