Association between biological ageing and periodontitis: Evidence from a cross-sectional survey and multi-omics Mendelian randomization analysis

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2024-07-02 DOI:10.1111/jcpe.14040

Zhendong Huang, Simin Peng, Ting Cen, Xiaoxuan Wang, Li Ma, Zhengguo Cao

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引用次数: 0

Abstract

Aim

To investigate the relationship and potential causality between biological ageing and periodontitis.

Materials and Methods

We obtained the National Health and Nutrition Examination Survey (NHANES) and genome-wide association study (GWAS) summary statistics as well as single-cell sequencing data. Multivariate regression analysis based on cross-sectional data, Mendelian randomization (MR) and multi-omics integration analysis were employed to explore the causal association and potential molecular mechanisms between biological ageing and periodontitis. Additionally, two-step MR mediation analysis explored the risk factors in biological ageing-mediated periodontitis.

Results

We analysed data from 3189 participants in the NHANES data and found that higher biological age was associated with increased risk of periodontitis. MR analyses revealed causal associations between biological age measures and periodontitis risk. Frailty (odds ratio [OR] = 2.08, 95% confidence interval [CI]: 1.04–4.18, p = .039) and GrimAge acceleration (OR = 1.16, 95% CI: 1.01–1.32, p = .033) were causally associated with periodontitis risk, and these results were validated in a large-scale meta-periodontitis GWAS dataset. Additionally, the risk effects of body mass index, waist circumference and lifetime smoking on periodontitis were partially mediated by frailty and GrimAge acceleration.

Conclusions

Evidence from cross-sectional survey and MR analysis suggests that biological ageing increases the risk of periodontitis. Additionally, improving the associated risk factors can help prevent both ageing and periodontitis.

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生物老化与牙周炎之间的关系：横断面调查和多组学孟德尔随机分析的证据。

目的：研究生物老化与牙周炎之间的关系和潜在因果关系：我们获得了美国国家健康与营养调查（NHANES）和全基因组关联研究（GWAS）的汇总统计数据以及单细胞测序数据。我们采用了基于横截面数据的多元回归分析、孟德尔随机化（MR）和多组学整合分析来探讨生物老化与牙周炎之间的因果关系和潜在的分子机制。此外，两步MR中介分析还探讨了生物老化介导的牙周炎的风险因素：我们分析了 3189 名 NHANES 数据参与者的数据，发现生理年龄越高，患牙周炎的风险越高。磁共振分析显示，生理年龄指标与牙周炎风险之间存在因果关系。虚弱（比值比 [OR] = 2.08，95% 置信区间 [CI]：1.04-4.18，p = .039）和 GrimAge 加速（比值比 [OR] = 1.16，95% 置信区间 [CI]：1.01-1.32，p = .033）与牙周炎风险存在因果关系，这些结果在大规模元牙周炎 GWAS 数据集中得到了验证。此外，体质指数、腰围和终生吸烟对牙周炎的风险影响部分由虚弱和GrimAge加速度介导：来自横断面调查和磁共振分析的证据表明，生物老化会增加牙周炎的风险。此外，改善相关风险因素有助于预防老化和牙周炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.