Inhalational exposure history is associated with differential sinonasal gene expression profiles and clinical outcomes in chronic rhinosinusitis patients: A pilot study

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2024-07-03 DOI:10.1002/alr.23403

Cameron P. Worden MD, Brian D. Thorp MD, Charles S. Ebert Jr. MD, MPH, Cristine N. Klatt-Cromwell MD, Brent A. Senior MD, Adam J. Kimple MD, PhD, Meghan E. Rebuli PhD, Ilona Jaspers PhD

引用次数: 0

Abstract

Key points

Inhalational exposure (IE) history assessment is important and may guide chronic rhinosinusitis disease management.
Combined exposure status was the most significant factor across differential gene expression analyse
IE history was associated with pro-inflammatory transcriptome changes and worse clinical outcomes.

查看原文本刊更多论文

吸入接触史与慢性鼻炎患者鼻窦基因表达谱和临床结果的差异有关：一项试点研究。

要点：吸入性暴露（IE）史评估非常重要，可指导慢性鼻炎的疾病管理。综合暴露状态是影响不同基因表达的最重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.