Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint.

IF 0.9 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Indian journal of public health Pub Date : 2024-04-01 Epub Date: 2024-06-29 DOI:10.4103/ijph.ijph_809_23

Sinjini Sarkar, Ranita Pal, Trisha Choudhury, Manisha Vernekar, Partha Nath, Vilas D Nasare

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引用次数: 0

Abstract

Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds and plays a crucial role in their cytotoxic activity. This study investigated a SAC component, Budding Uninhibited by Benzimidazoles 3 (BUB3), its expression, and genetic variants in advanced ovarian cancer patients treated with paclitaxel-carboplatin chemotherapy. Among 80 patients, BUB3 expression correlated with chemosensitivity, suggesting its potential as a predictive marker for chemotherapy response. However, high BUB3 expression was associated with a higher risk of poor survival. In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient's physical quality of life.

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基因变异影响化疗结果：纺锤体组装检查点的作用

癌症患者承受着复杂的化学毒性。药物基因组学可以预测患者对治疗的反应以及对严重副作用的易感性，从而帮助对患者进行分层。纺锤体组装检查点（SAC）是铂类和紫杉类化合物激活的一个重要途径，在其细胞毒性活性中起着至关重要的作用。本研究调查了接受紫杉醇-卡铂化疗的晚期卵巢癌患者中的SAC成分--苯并咪唑类抑制芽生3（BUB3）、其表达和遗传变异。在80名患者中，BUB3的表达与化疗敏感性相关，这表明它有可能成为化疗反应的预测标志物。然而，BUB3的高表达与较高的不良生存风险相关。此外，BUB3的基因多态性（rs11248416和rs11248419）与化疗相关毒性显著相关，其中rs11248416对患者的身体生活质量有负面影响。

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来源期刊

Indian journal of public health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： Indian Journal of Public Health is a peer-reviewed international journal published Quarterly by the Indian Public Health Association. It is indexed / abstracted by the major international indexing systems like Index Medicus/MEDLINE, SCOPUS, PUBMED, etc. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles. The Indian Journal of Public Health publishes articles of authors from India and abroad with special emphasis on original research findings that are relevant for developing country perspectives including India. The journal considers publication of articles as original article, review article, special article, brief research article, CME / Education forum, commentary, letters to editor, case series reports, etc. The journal covers population based studies, impact assessment, monitoring and evaluation, systematic review, meta-analysis, clinic-social studies etc., related to any domain and discipline of public health, specially relevant to national priorities, including ethical and social issues. Articles aligned with national health issues and policy implications are prefered.