The EQ-5D-5L valuation study for Trinidad and Tobago.

IF 3.2 2区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Health and Quality of Life Outcomes Pub Date : 2024-07-02 DOI:10.1186/s12955-024-02266-7

Henry Bailey, Marcel F Jonker, Eleanor Pullenayegum, Fanni Rencz, Bram Roudijk

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引用次数: 0

Abstract

Purpose: The 2016 EQ-5D-3L value set for Trinidad and Tobago (T&T) allows for the calculation of EQ-5D-5L values via the crosswalk algorithm. The 2016 value set was based on methods predating the EQ-VT protocol, now considered the gold standard for developing EQ-5D value sets. Furthermore, direct elicitation of EQ-5D-5L is preferred over crosswalked values. This study aimed to produce an EQ-5D-5L value set for T&T.

Methods: A representative sample (age, sex, geography) of adults each completed 10 composite Time Trade-Off (cTTO) tasks and 12 Discrete Choice Experiment (DCE) tasks in face-to-face interviews. The cTTO data were analyzed using a Tobit model that corrects for heteroskedasticity. DCE data were analyzed using a mixed logit model. The cTTO and DCE data were combined in hybrid models.

Results: One thousand and seventy-nine adults completed the valuation interviews. Among the modelling approaches that were explored, the hybrid heteroskedastic Tobit model produced all internally consistent, statistically significant coefficients, and performed best in terms of out-of-sample predictivity for single states. Compared to the existing EQ-5D-5L crosswalk set, the new value set had a higher number of negative values (236 or 7.6% versus 21 or 0.7%). The mean absolute difference was 0.157 and the correlation coefficient between the two sets was 0.879.

Conclusion: This study provides a value set for the EQ-5D-5L for T&T using the EQ-VT protocol. We recommend this value set for QALY computations relating to T&T.

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特立尼达和多巴哥 EQ-5D-5L 评估研究。

目的：特立尼达和多巴哥（T&T）2016 年 EQ-5D-3L 值集可通过交叉算法计算 EQ-5D-5L 值。2016 年的数值集基于 EQ-VT 协议之前的方法，而 EQ-VT 协议目前被认为是开发 EQ-5D 数值集的黄金标准。此外，直接征询 EQ-5D-5L 值比横道值更受欢迎。本研究旨在为泰和泰制作一套 EQ-5D-5L 值集：具有代表性的成人样本（年龄、性别、地域）在面对面访谈中分别完成了 10 项综合时间权衡（cTTO）任务和 12 项离散选择实验（DCE）任务。cTTO 数据采用修正了异方差的 Tobit 模型进行分析。DCE 数据采用混合 logit 模型进行分析。在混合模型中将 cTTO 和 DCE 数据合并：共有 179 名成年人完成了估值访谈。在探索的建模方法中，混合异方差 Tobit 模型产生了所有内部一致、具有统计意义的系数，并且在单一状态的样本外预测性方面表现最佳。与现有的 EQ-5D-5L 交叉图集相比，新值集的负值数量更多（236 或 7.6% 对 21 或 0.7%）。平均绝对差值为 0.157，两套值之间的相关系数为 0.879：这项研究为使用 EQ-VT 协议的泰和泰 EQ-5D-5L 提供了一个值集。我们推荐在计算与 T&T 相关的 QALY 时使用该值集。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health and Quality of Life Outcomes 医学-卫生保健

CiteScore

7.30

自引率

2.80%

发文量

154

审稿时长

3-8 weeks

期刊介绍： Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain. Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.