The role of light emitting diode in wound healing: A systematic review of experimental studies

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2024-07-02 DOI:10.1002/cbf.4086

Rebeca Barbosa da Rocha, Dakson Douglas Araújo, Fabrício dos Santos Machado, Vinicius Saura Cardoso, Ana Jérsia Araújo, José Delano Barreto Marinho-Filho

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引用次数: 0

Abstract

Wounds represent a growing global issue demanding increased attention. To expedite wound healing, technologies are under development, and light emitting diode (LED) devices of varying wavelengths are being explored for their stimulating influence on the healing process. This article presents a systematic literature review aiming to compile, organize, and analyze the impacts of LED devices on wound healing. This review is registered on the PROSPERO platform [CRD42023403870]. Two blinded authors conducted searches in the Pubmed, Web of Science, Scopus, Embase, and ScienceDirect databases. In vitro and in vivo experimental studies assessing LED utilization in the wound healing process were included. The search yielded 1010 studies, of which 27 were included in the review. It was identified that LED stimulates different healing pathways, promoting enhanced cell proliferation and migration, angiogenesis stimulation, increased collagen deposition, and modulation of the inflammatory response. Thus, it can be concluded that the LED stimulates cellular and molecular processes contingent on the utilized parameters. The effects depend on the standards used. Cell migration and proliferation were better influenced by green and red LED. The extracellular matrix components and angiogenesis were regulated by all wavelengths and the modulation of inflammation was mediated by green, red, and infrared LEDs.

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发光二极管在伤口愈合中的作用：实验研究的系统回顾。

伤口是一个日益严重的全球性问题，需要越来越多的关注。为了加速伤口愈合，各种技术正在不断发展，不同波长的发光二极管（LED）设备也在不断探索其对伤口愈合过程的刺激作用。本文是一篇系统性的文献综述，旨在汇编、整理和分析 LED 设备对伤口愈合的影响。本综述已在 PROSPERO 平台上注册 [CRD42023403870]。两位盲人作者在 Pubmed、Web of Science、Scopus、Embase 和 ScienceDirect 数据库中进行了检索。其中包括评估 LED 在伤口愈合过程中应用情况的体外和体内实验研究。搜索结果包括 1010 项研究，其中 27 项被纳入综述。研究发现，LED 可刺激不同的愈合途径，促进细胞增殖和迁移、刺激血管生成、增加胶原沉积和调节炎症反应。因此，可以得出这样的结论：LED 刺激细胞和分子过程取决于所使用的参数。效果取决于所使用的标准。绿色和红色 LED 对细胞迁移和增殖的影响更大。细胞外基质成分和血管生成受到所有波长 LED 的调节，炎症的调节则受绿色、红色和红外线 LED 的介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.