Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-07-03 DOI:10.1111/ijpo.13149

Zhila Semnani-Azad, Mohammad L. Rahman, Melina Arguin, Myriam Doyon, Patrice Perron, Luigi Bouchard, Marie-France Hivert

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引用次数: 0

Abstract

Objective

This study identified metabolite modules associated with adiposity and body fat distribution in childhood using gold-standard measurements.

Methods

We used cross-sectional data from 329 children at mid-childhood (age 5.3 ± 0.3 years; BMI 15.7 ± 1.5 kg/m²) from the Genetics of Glucose regulation in Gestation and Growth (Gen3G), a prospective pre-birth cohort. We quantified 1038 plasma metabolites and measured body composition using the gold-standard dual-energy x-ray absorptiometry (DXA), in addition to skinfold, waist circumference, and BMI. We applied weighted-correlation network analysis to identify a network of highly correlated metabolite modules. Spearman's partial correlations were applied to determine the associations of adiposity with metabolite modules and individual metabolites with false discovery rate (FDR) correction.

Results

We identified a ‘green’ module of 120 metabolites, primarily comprised of lipids (mostly sphingomyelins and phosphatidylcholine), that showed positive correlations (all FDR p < 0.05) with DXA estimates of total and truncal fat (ρ_adjusted = 0.11–0.19), skinfold measures (ρ_adjusted = 0.09–0.26), and BMI and waist circumference (ρ_adjusted = 0.15 and 0.18, respectively). These correlations were similar when stratified by sex. Within this module, sphingomyelin (d18:2/14:0, d18:1/14:1)*, a sphingomyelin sub-specie that is an important component of cell membranes, showed the strongest associations.

Conclusions

A module of metabolites was associated with adiposity measures in childhood.

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儿童期脂肪和身体成分的血浆代谢组学特征：妊娠和生长过程中葡萄糖调节的遗传学研究。

目的：本研究采用黄金标准测量方法，确定了与儿童期脂肪和体脂分布相关的代谢物模块：本研究采用黄金标准测量方法，确定了与儿童期肥胖和体脂分布相关的代谢物模块：我们使用了 329 名儿童（年龄为 5.3 ± 0.3 岁；体重指数为 15.7 ± 1.5 kg/m2）的横断面数据，这些数据来自妊娠和生长过程中的葡萄糖调节遗传学（Gen3G），这是一个前瞻性的出生前队列。我们对 1038 种血浆代谢物进行了量化，并使用黄金标准的双能 X 射线吸收测定法（DXA）测量了身体成分，此外还测量了皮褶、腰围和体重指数。我们采用加权相关网络分析来确定高度相关的代谢物模块网络。应用斯皮尔曼偏相关来确定脂肪量与代谢物模块和单个代谢物之间的关联，并对错误发现率（FDR）进行校正：我们发现了一个由120种代谢物组成的 "绿色 "模块，主要由脂类（主要是鞘磷脂和磷脂酰胆碱）、皮褶测量值（ρ调整后=0.09-0.26）、体重指数（BMI）和腰围（ρ调整后分别=0.15和0.18）呈正相关。这些相关性在按性别分层时相似。在该模块中，鞘磷脂（d18:2/14:0, d18:1/14:1）*（一种鞘磷脂亚种，是细胞膜的重要组成部分）显示出最强的相关性：结论：代谢物模块与儿童期的脂肪测量相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.