Degradation Behavior of Medical MgZZC-1 in Various Simulated Body Fluids

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2024-07-03 DOI:10.1021/acs.langmuir.4c01715

Jie Pan, Jinling Zhang*, Yelei Li, Fanxi Yang, Yanchong Yu* and Shebin Wang,

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引用次数: 0

Abstract

Magnesium-based biodegradable metal bone implants exhibit superior mechanical properties compared to biodegradable polymers for orthopedic and cardiovascular stents. In this study, MgZZC-x (x = 1, 1.2) alloys were screened by in vitro biocompatibility tests in three simulated body fluids under nontoxic conditions. The MgZZC-1 alloys with better biocompatibility were selected to predict the days required for complete degradation. The evolution of degradation products was analyzed, and the mechanism of formation of the product film was inferred. A degradation kinetic model was established to investigate the effect of MEM components on the degradation of the alloys. The results demonstrate that the proteins in MEM can greatly retard the degradation progress by attaching to the surface of MgZZC-1 alloys, which are predicted to degrade completely within 341 days. The carbonate and phosphate buffers were adjusted to pH in MEM solution, delaying the degradation of magnesium alloys. This process in MEM more accurately reflects the actual degradation in the body and is superior to that in Hanks and SBF solutions. This study will promote the application of biodegradable materials in clinical medicine.

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医用 MgZZC-1 在各种模拟体液中的降解行为

与用于骨科和心血管支架的生物可降解聚合物相比，镁基生物可降解金属骨植入物具有更优越的机械性能。本研究在无毒条件下，在三种模拟体液中通过体外生物相容性测试对 MgZZC-x（x = 1，1.2）合金进行了筛选。筛选出生物相容性较好的 MgZZC-1 合金，并预测了完全降解所需的天数。分析了降解产物的演变过程，并推断了产物膜的形成机理。建立了降解动力学模型，以研究 MEM 成分对合金降解的影响。结果表明，MEM 中的蛋白质可通过附着在 MgZZC-1 合金表面而大大延缓降解进程，预计 MgZZC-1 合金将在 341 天内完全降解。碳酸盐和磷酸盐缓冲液被调整到 MEM 溶液的 pH 值，延缓了镁合金的降解。MEM 中的这一过程更准确地反映了体内的实际降解情况，优于 Hanks 和 SBF 溶液中的降解过程。这项研究将促进生物降解材料在临床医学中的应用。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).