Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring

IF 20.6 1区 医学 Q1 MICROBIOLOGY
Shilan Wang, Yingzhi Liu, Wing Hung Tam, Jessica Y.L. Ching, Wenye Xu, Shuai Yan, Biyan Qin, Ling Lin, Ye Peng, Jie Zhu, Chun Pan Cheung, Ka Long Ip, Yuen Man Wong, Pui Kuan Cheong, Yuk Ling Yeung, Wing Him Betty Kan, Ting Fan Leung, Tak Yeung Leung, Eugene B. Chang, David T. Rubin, Lin Zhang
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Abstract

The impact of gestational diabetes mellitus (GDM) on maternal or infant microbiome trajectory remains poorly understood. Utilizing large-scale longitudinal fecal samples from 264 mother-baby dyads, we present the gut microbiome trajectory of the mothers throughout pregnancy and infants during the first year of life. GDM mothers had a distinct microbiome diversity and composition during the gestation period. GDM leaves fingerprints on the infant’s gut microbiome, which are confounded by delivery mode. Further, Clostridium species positively correlate with a larger head circumference at month 12 in male offspring but not females. The gut microbiome of GDM mothers with male fetuses displays depleted gut-brain modules, including acetate synthesis I and degradation and glutamate synthesis II. The gut microbiome of female infants of GDM mothers has higher histamine degradation and dopamine degradation. Together, our integrative analysis indicates that GDM affects maternal and infant gut composition, which is associated with sexually dimorphic infant head growth.

Abstract Image

母体妊娠糖尿病与男性后代肠道微生物组组成改变和头围异常有关
人们对妊娠糖尿病(GDM)对母体或婴儿微生物组轨迹的影响仍然知之甚少。我们利用来自 264 对母婴的大规模纵向粪便样本,展示了母亲在整个孕期和婴儿出生后第一年的肠道微生物组轨迹。GDM 母亲在妊娠期具有独特的微生物组多样性和组成。GDM 在婴儿的肠道微生物组中留下了指纹,这些指纹与分娩方式有关。此外,梭状芽孢杆菌的种类与男婴第 12 个月时头围的增大呈正相关,但与女婴无关。GDM 母亲与男胎的肠道微生物组显示出肠道-大脑模块的衰竭,包括醋酸合成 I 和降解以及谷氨酸合成 II。GDM母亲所生女婴的肠道微生物组具有较高的组胺降解和多巴胺降解能力。我们的综合分析表明,GDM 会影响母婴的肠道组成,这与婴儿头部生长的性别双态性有关。
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来源期刊
Cell host & microbe
Cell host & microbe 生物-微生物学
CiteScore
45.10
自引率
1.70%
发文量
201
审稿时长
4-8 weeks
期刊介绍: Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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